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Target Report Card

Target Name and Classification

Target ID CHEMBL5368
Preferred Name Amiloride-sensitive cation channel 3
Synonyms ACCN3 | ASIC3 | ASIC3 | Acid-sensing ion channel 3 | Amiloride-sensitive cation channel 3 | Neuronal amiloride-sensitive cation channel 3 | SLNAC1 | TNAC1 | Testis sodium channel 1 | hASIC3 | hTNaC1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • ion channel > ligand-gated ion channel > acid-sensing ion channel

Target Components

Component Description Relationship Accession
Acid-sensing ion channel 3 SINGLE PROTEIN Q9UHC3

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000213199
Ensembl ENSG00000213199
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO Molecular Function GO:0005261 (cation channel activity)
GO:0005272 (sodium channel activity)
GO:0015280 (ligand-gated sodium channel activity)
GO:0030165 (PDZ domain binding)
GO:0042931 (enterobactin transporter activity)
GO:0044736 (acid-sensing ion channel activity)
GO Biological Process GO:0006811 (ion transport)
GO:0006812 (cation transport)
GO:0006814 (sodium ion transport)
GO:0007165 (signal transduction)
GO:0007600 (sensory perception)
GO:0009408 (response to heat)
GO:0009612 (response to mechanical stimulus)
GO:0010447 (response to acidic pH)
GO:0034220 (ion transmembrane transport)
GO:0035725 (sodium ion transmembrane transport)
GO:0042930 (enterobactin transport)
GO:0050907 (detection of chemical stimulus involved in sensory perception)
GO:0050915 (sensory perception of sour taste)
GO:0050961 (detection of temperature stimulus involved in sensory perception)
GO:0050965 (detection of temperature stimulus involved in sensory perception of pain)
GO:0050966 (detection of mechanical stimulus involved in sensory perception of pain)
GO:0050968 (detection of chemical stimulus involved in sensory perception of pain)
GO:0050974 (detection of mechanical stimulus involved in sensory perception)
GO:0098655 (cation transmembrane transport)
Wikipedia ACCN3

Target Cross References - Protein

Human Protein Atlas ENSG00000213199
Guide to Pharmacology 686
Open Targets ENSG00000213199
PharmGKB PA24435
Pharos Q9UHC3 (Tchem)
Reactome R-HSA-2672351 (Stimuli-sensing channels.)
UniProt B2R9V0 O60263 O75906 Q59FN9 Q9UER8 Q9UHC3 Q9UHC4

Target Cross References - Domain

InterPro IPR001873 (ENaC.)
IPR004724 (ENaC_chordates.)
IPR020903 (ENaC_CS.)
Pfam PF00858 (ASC)