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Target Report Card

Target Name and Classification

Target ID CHEMBL5358
Preferred Name Eukaryotic translation initiation factor 2-alpha kinase 4
Synonyms EIF2AK4 | Eukaryotic translation initiation factor 2-alpha kinase 4 | GCN2 | GCN2-like protein | KIAA1338 | eIF-2-alpha kinase GCN2
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > other protein kinase group > other protein kinase pek family > other protein kinase gcn2 subfamily

Target Components

Component Description Relationship Accession
eIF-2-alpha kinase GCN2 SINGLE PROTEIN Q9P2K8

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000128829
Ensembl ENSG00000128829
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005844 (polysome)
GO:0022626 (cytosolic ribosome)
GO Molecular Function GO:0000049 (tRNA binding)
GO:0000166 (nucleotide binding)
GO:0003723 (RNA binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0004694 (eukaryotic translation initiation factor 2alpha kinase activity)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO Biological Process GO:0000077 (DNA damage checkpoint)
GO:0002230 (positive regulation of defense response to virus by host)
GO:0002250 (adaptive immune response)
GO:0002286 (T cell activation involved in immune response)
GO:0002376 (immune system process)
GO:0002821 (positive regulation of adaptive immune response)
GO:0006417 (regulation of translation)
GO:0006446 (regulation of translational initiation)
GO:0006468 (protein phosphorylation)
GO:0007049 (cell cycle)
GO:0007050 (cell cycle arrest)
GO:0007399 (nervous system development)
GO:0007612 (learning)
GO:0007616 (long-term memory)
GO:0010998 (regulation of translational initiation by eIF2 alpha phosphorylation)
GO:0016032 (viral process)
GO:0016310 (phosphorylation)
GO:0019081 (viral translation)
GO:0032057 (negative regulation of translational initiation in response to stress)
GO:0032792 (negative regulation of CREB transcription factor activity)
GO:0034198 (cellular response to amino acid starvation)
GO:0034644 (cellular response to UV)
GO:0036492 (eiF2alpha phosphorylation in response to endoplasmic reticulum stress)
GO:0039520 (induction by virus of host autophagy)
GO:0044828 (negative regulation by host of viral genome replication)
GO:0045665 (negative regulation of neuron differentiation)
GO:0045947 (negative regulation of translational initiation)
GO:0046777 (protein autophosphorylation)
GO:0051607 (defense response to virus)
GO:0060259 (regulation of feeding behavior)
GO:0060733 (regulation of eIF2 alpha phosphorylation by amino acid starvation)
GO:0070417 (cellular response to cold)
GO:0071264 (positive regulation of translational initiation in response to starvation)
GO:1900273 (positive regulation of long-term synaptic potentiation)
GO:1990138 (neuron projection extension)
GO:1990253 (cellular response to leucine starvation)
Wikipedia EIF2AK4

Target Cross References - Protein

Human Protein Atlas ENSG00000128829
IntAct Q9P2K8
Guide to Pharmacology 2018
Open Targets ENSG00000128829
PharmGKB PA134947616
Pharos Q9P2K8 (Tchem)
UniProt C9JEC4 Q69YL7 Q6DC97 Q96GN6 Q9H5K1 Q9NSQ3 Q9NSZ5 Q9P2K8 Q9UJ56

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR006575 (RWD-domain.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR011009 (Kinase-like_dom_sf.)
IPR016135 (UBQ-conjugating_enzyme/RWD.)
IPR016255 (Gcn2.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR024435 (HisRS-related_dom.)
IPR036621 (Anticodon-bd_dom_sf.)
Pfam PF00069 (Pkinase)
PF05773 (RWD)
PF12745 (HGTP_anticodon2)