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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL5353
Target Type SINGLE PROTEIN
Preferred Name Acyl-CoA desaturase 1
Synonyms Acyl-CoA desaturase 1 | Delta(9)-desaturase 1 | Delta-9 desaturase 1 | Fatty acid desaturase 1 | Scd1 | Stearoyl-CoA desaturase 1
Organism Mus musculus
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Acyl-CoA desaturase 1 SINGLE PROTEIN P13516

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005783 (endoplasmic reticulum)
GO:0005789 (endoplasmic reticulum membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0030176 (integral component of endoplasmic reticulum membrane)
GO:0031090 (organelle membrane)
GO:0043231 (intracellular membrane-bounded organelle)
GO Molecular Function GO:0004768 (stearoyl-CoA 9-desaturase activity)
GO:0005506 (iron ion binding)
GO:0016491 (oxidoreductase activity)
GO:0016717 (oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water)
GO:0032896 (palmitoyl-CoA 9-desaturase activity)
GO:0046872 (metal ion binding)
GO Biological Process GO:0006629 (lipid metabolic process)
GO:0006631 (fatty acid metabolic process)
GO:0006633 (fatty acid biosynthetic process)
GO:0006636 (unsaturated fatty acid biosynthetic process)
GO:0006641 (triglyceride metabolic process)
GO:0008610 (lipid biosynthetic process)
GO:0010873 (positive regulation of cholesterol esterification)
GO:0033561 (regulation of water loss via skin)
GO:0034434 (sterol esterification)
GO:0034435 (cholesterol esterification)
GO:0044130 (negative regulation of growth of symbiont in host)
GO:0048733 (sebaceous gland development)
GO:0050830 (defense response to Gram-positive bacterium)
GO:0050872 (white fat cell differentiation)
GO:0050873 (brown fat cell differentiation)
GO:0055114 (oxidation-reduction process)
GO:0070542 (response to fatty acid)
GO:1903699 (tarsal gland development)
GO:1903966 (monounsaturated fatty acid biosynthetic process)

Target Cross References - Protein

canSAR P13516
Reactome R-MMU-2426168 (Activation of gene expression by SREBF (SREBP).)
R-MMU-75105 (Fatty Acyl-CoA Biosynthesis.)
UniProt P13516 Q922I6

Target Cross References - Domain

InterPro IPR001522 (FADS-1_CS.)
IPR005804 (FA_desaturase_dom.)
IPR015876 (Acyl-CoA_DS.)
Pfam PF00487 (FA_desaturase)

Target Cross References - Structure

PDBe 4YMK
CREDO 4YMK
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