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Target Report Card

Target Name and Classification

Target ID CHEMBL5334
Preferred Name Non-receptor tyrosine-protein kinase TNK1
Synonyms CD38 negative kinase 1 | Non-receptor tyrosine-protein kinase TNK1 | TNK1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > tk protein kinase group > tyrosine protein kinase ack family

Target Components

Component Description Relationship Accession
Non-receptor tyrosine-protein kinase TNK1 SINGLE PROTEIN Q13470

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000174292 ENSG00000283781
Ensembl ENSG00000174292 ENSG00000283781
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0016020 (membrane)
GO:0031234 (extrinsic component of cytoplasmic side of plasma membrane)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004713 (protein tyrosine kinase activity)
GO:0004715 (non-membrane spanning protein tyrosine kinase activity)
GO:0004871 (signal transducer activity)
GO:0005102 (receptor binding)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO Biological Process GO:0006468 (protein phosphorylation)
GO:0007169 (transmembrane receptor protein tyrosine kinase signaling pathway)
GO:0016310 (phosphorylation)
GO:0016477 (cell migration)
GO:0030154 (cell differentiation)
GO:0030308 (negative regulation of cell growth)
GO:0038083 (peptidyl-tyrosine autophosphorylation)
GO:0042127 (regulation of cell proliferation)
GO:0045087 (innate immune response)
GO:0046580 (negative regulation of Ras protein signal transduction)
GO:0046777 (protein autophosphorylation)

Target Cross References - Protein

canSAR Q13470
Human Protein Atlas ENSG00000174292 ENSG00000283781
IntAct Q13470
Guide to Pharmacology 2245
Open Targets ENSG00000174292 ENSG00000283781
PharmGKB PA36630
Pharos Q13470 (Tchem)
UniProt O95364 Q13470 Q8IYI4

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR001245 (Ser-Thr/Tyr_kinase_cat_dom.)
IPR001452 (SH3_domain.)
IPR008266 (Tyr_kinase_AS.)
IPR011009 (Kinase-like_dom_sf.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR020635 (Tyr_kinase_cat_dom.)
Pfam PF07714 (Pkinase_Tyr)