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Target Report Card

Target Name and Classification

Target ID CHEMBL5314
Preferred Name Tyrosine-protein kinase receptor TYRO3
Synonyms BYK | DTK | RSE | SKY | TIF | TYRO3 | Tyrosine-protein kinase BYK | Tyrosine-protein kinase DTK | Tyrosine-protein kinase RSE | Tyrosine-protein kinase SKY | Tyrosine-protein kinase TIF | Tyrosine-protein kinase receptor TYRO3
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > tk protein kinase group > tyrosine protein kinase axl family

Target Components

Component Description Relationship Accession
Tyrosine-protein kinase receptor TYRO3 SINGLE PROTEIN Q06418

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000092445
Ensembl ENSG00000092445
GO Cellular Component GO:0005634 (nucleus)
GO:0005635 (nuclear envelope)
GO:0005789 (endoplasmic reticulum membrane)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0001618 (virus receptor activity)
GO:0004672 (protein kinase activity)
GO:0004713 (protein tyrosine kinase activity)
GO:0004714 (transmembrane receptor protein tyrosine kinase activity)
GO:0004716 (receptor signaling protein tyrosine kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0043548 (phosphatidylinositol 3-kinase binding)
GO:0046982 (protein heterodimerization activity)
GO Biological Process GO:0001779 (natural killer cell differentiation)
GO:0006468 (protein phosphorylation)
GO:0007155 (cell adhesion)
GO:0007165 (signal transduction)
GO:0007218 (neuropeptide signaling pathway)
GO:0007283 (spermatogenesis)
GO:0014065 (phosphatidylinositol 3-kinase signaling)
GO:0016032 (viral process)
GO:0016310 (phosphorylation)
GO:0018108 (peptidyl-tyrosine phosphorylation)
GO:0021885 (forebrain cell migration)
GO:0023014 (signal transduction by protein phosphorylation)
GO:0030168 (platelet activation)
GO:0032940 (secretion by cell)
GO:0034122 (negative regulation of toll-like receptor signaling pathway)
GO:0034446 (substrate adhesion-dependent cell spreading)
GO:0042698 (ovulation cycle)
GO:0043277 (apoptotic cell clearance)
GO:0043491 (protein kinase B signaling)
GO:0043524 (negative regulation of neuron apoptotic process)
GO:0045824 (negative regulation of innate immune response)
GO:0046718 (viral entry into host cell)
GO:0046777 (protein autophosphorylation)
GO:0050728 (negative regulation of inflammatory response)
GO:0051250 (negative regulation of lymphocyte activation)
GO:0060068 (vagina development)
GO:0070050 (neuron cellular homeostasis)
GO:0070527 (platelet aggregation)
Wikipedia TYRO3

Target Cross References - Protein

canSAR Q06418
Human Protein Atlas ENSG00000092445
IntAct Q06418
Guide to Pharmacology 1836
Open Targets ENSG00000092445
PharmGKB PA37097
Pharos Q06418 (Tchem)
UniProt O14953 Q06418 Q86VR3

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR001245 (Ser-Thr/Tyr_kinase_cat_dom.)
IPR003598 (Ig_sub2.)
IPR003599 (Ig_sub.)
IPR003961 (FN3_dom.)
IPR007110 (Ig-like_dom.)
IPR008266 (Tyr_kinase_AS.)
IPR011009 (Kinase-like_dom_sf.)
IPR013098 (Ig_I-set.)
IPR013783 (Ig-like_fold.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR020635 (Tyr_kinase_cat_dom.)
IPR036116 (FN3_sf.)
IPR036179 (Ig-like_dom_sf.)
Pfam PF00041 (fn3)
PF07679 (I-set)
PF07714 (Pkinase_Tyr)

Target Cross References - Structure