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Target Report Card

Target Name and Classification

Target ID CHEMBL5311
Preferred Name Serine/threonine-protein kinase receptor R3
Synonyms ACVRL1 | ACVRLK1 | ALK-1 | ALK1 | Activin receptor-like kinase 1 | SKR3 | Serine/threonine-protein kinase receptor R3 | TGF-B superfamily receptor type I | TSR-I
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > tkl protein kinase group > tkl protein kinase stkr family > tkl protein kinase stkr type 1 subfamily

Target Components

Component Description Relationship Accession
Serine/threonine-protein kinase receptor R3 SINGLE PROTEIN P37023

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL2109295 ASCRINVACUMAB Serine/threonine-protein kinase receptor R3 inhibitor 2 PubMed
CHEMBL3545322 PANULISIB Serine/threonine-protein kinase receptor R3 inhibitor 1 PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000139567
Ensembl ENSG00000139567
GO Cellular Component GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0009986 (cell surface)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0030425 (dendrite)
GO:0043025 (neuronal cell body)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0004675 (transmembrane receptor protein serine/threonine kinase activity)
GO:0004702 (receptor signaling protein serine/threonine kinase activity)
GO:0005024 (transforming growth factor beta-activated receptor activity)
GO:0005025 (transforming growth factor beta receptor activity, type I)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016361 (activin receptor activity, type I)
GO:0016740 (transferase activity)
GO:0019901 (protein kinase binding)
GO:0046332 (SMAD binding)
GO:0046872 (metal ion binding)
GO:0048185 (activin binding)
GO:0050431 (transforming growth factor beta binding)
GO:0098821 (BMP receptor activity)
GO Biological Process GO:0001525 (angiogenesis)
GO:0001666 (response to hypoxia)
GO:0001701 (in utero embryonic development)
GO:0001936 (regulation of endothelial cell proliferation)
GO:0001937 (negative regulation of endothelial cell proliferation)
GO:0001938 (positive regulation of endothelial cell proliferation)
GO:0001946 (lymphangiogenesis)
GO:0001955 (blood vessel maturation)
GO:0001974 (blood vessel remodeling)
GO:0002043 (blood vessel endothelial cell proliferation involved in sprouting angiogenesis)
GO:0003203 (endocardial cushion morphogenesis)
GO:0006275 (regulation of DNA replication)
GO:0006355 (regulation of transcription, DNA-templated)
GO:0006468 (protein phosphorylation)
GO:0007162 (negative regulation of cell adhesion)
GO:0007165 (signal transduction)
GO:0007178 (transmembrane receptor protein serine/threonine kinase signaling pathway)
GO:0007179 (transforming growth factor beta receptor signaling pathway)
GO:0008015 (blood circulation)
GO:0008217 (regulation of blood pressure)
GO:0008285 (negative regulation of cell proliferation)
GO:0010596 (negative regulation of endothelial cell migration)
GO:0010629 (negative regulation of gene expression)
GO:0010862 (positive regulation of pathway-restricted SMAD protein phosphorylation)
GO:0016310 (phosphorylation)
GO:0023014 (signal transduction by protein phosphorylation)
GO:0030308 (negative regulation of cell growth)
GO:0030336 (negative regulation of cell migration)
GO:0030509 (BMP signaling pathway)
GO:0030513 (positive regulation of BMP signaling pathway)
GO:0032332 (positive regulation of chondrocyte differentiation)
GO:0032924 (activin receptor signaling pathway)
GO:0035313 (wound healing, spreading of epidermal cells)
GO:0035912 (dorsal aorta morphogenesis)
GO:0043535 (regulation of blood vessel endothelial cell migration)
GO:0043537 (negative regulation of blood vessel endothelial cell migration)
GO:0045602 (negative regulation of endothelial cell differentiation)
GO:0045603 (positive regulation of endothelial cell differentiation)
GO:0045766 (positive regulation of angiogenesis)
GO:0045893 (positive regulation of transcription, DNA-templated)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0048514 (blood vessel morphogenesis)
GO:0051291 (protein heterooligomerization)
GO:0051895 (negative regulation of focal adhesion assembly)
GO:0060836 (lymphatic endothelial cell differentiation)
GO:0060840 (artery development)
GO:0060841 (venous blood vessel development)
GO:0061154 (endothelial tube morphogenesis)
GO:0061298 (retina vasculature development in camera-type eye)
GO:0071560 (cellular response to transforming growth factor beta stimulus)
GO:0071773 (cellular response to BMP stimulus)
GO:0090500 (endocardial cushion to mesenchymal transition)
GO:2000279 (negative regulation of DNA biosynthetic process)
Wikipedia ACVRL1

Target Cross References - Protein

canSAR P37023
CGD Hereditary hemorrhagic telangiectasia, type 2
Human Protein Atlas ENSG00000139567
IntAct P37023
Guide to Pharmacology 1784
Open Targets ENSG00000139567
PharmGKB PA24496
Pharos P37023 (Tchem)
Reactome R-HSA-201451 (Signaling by BMP.)
UniProt A6NGA8 P37023

Target Cross References - Domain

InterPro IPR000333 (TGFB_receptor.)
IPR000719 (Prot_kinase_dom.)
IPR001245 (Ser-Thr/Tyr_kinase_cat_dom.)
IPR003605 (GS_dom.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR011009 (Kinase-like_dom_sf.)
IPR017441 (Protein_kinase_ATP_BS.)
Pfam PF07714 (Pkinase_Tyr)
PF08515 (TGF_beta_GS)

Target Cross References - Structure