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Target Report Card

Target Name and Classification

Target ID CHEMBL5310
Preferred Name Activin receptor type-1B
Synonyms ACTR-IB | ACVR1B | ACVRLK4 | ALK-4 | ALK4 | Activin receptor type IB | Activin receptor type-1B | Activin receptor-like kinase 4 | SKR2 | Serine/threonine-protein kinase receptor R2
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > tkl protein kinase group > tkl protein kinase stkr family > tkl protein kinase stkr type 1 subfamily

Target Components

Component Description Relationship Accession
Activin receptor type-1B SINGLE PROTEIN P36896

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000135503
Ensembl ENSG00000135503
GO Cellular Component GO:0005829 (cytosol)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0009986 (cell surface)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0043235 (receptor complex)
GO:0048179 (activin receptor complex)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0004675 (transmembrane receptor protein serine/threonine kinase activity)
GO:0004702 (receptor signaling protein serine/threonine kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016361 (activin receptor activity, type I)
GO:0016740 (transferase activity)
GO:0017002 (activin-activated receptor activity)
GO:0019838 (growth factor binding)
GO:0031625 (ubiquitin protein ligase binding)
GO:0034711 (inhibin binding)
GO:0046332 (SMAD binding)
GO:0046872 (metal ion binding)
GO:0048185 (activin binding)
GO Biological Process GO:0000082 (G1/S transition of mitotic cell cycle)
GO:0001701 (in utero embryonic development)
GO:0001942 (hair follicle development)
GO:0006355 (regulation of transcription, DNA-templated)
GO:0006468 (protein phosphorylation)
GO:0007165 (signal transduction)
GO:0007178 (transmembrane receptor protein serine/threonine kinase signaling pathway)
GO:0007417 (central nervous system development)
GO:0009966 (regulation of signal transduction)
GO:0010628 (positive regulation of gene expression)
GO:0010629 (negative regulation of gene expression)
GO:0010862 (positive regulation of pathway-restricted SMAD protein phosphorylation)
GO:0016310 (phosphorylation)
GO:0018107 (peptidyl-threonine phosphorylation)
GO:0023014 (signal transduction by protein phosphorylation)
GO:0030308 (negative regulation of cell growth)
GO:0032924 (activin receptor signaling pathway)
GO:0032927 (positive regulation of activin receptor signaling pathway)
GO:0038092 (nodal signaling pathway)
GO:0045648 (positive regulation of erythrocyte differentiation)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0046545 (development of primary female sexual characteristics)
GO:0046777 (protein autophosphorylation)
GO:0097191 (extrinsic apoptotic signaling pathway)
GO:1901165 (positive regulation of trophoblast cell migration)
Wikipedia ACVR1B

Target Cross References - Protein

canSAR P36896
Human Protein Atlas ENSG00000135503
IntAct P36896
Guide to Pharmacology 1787
Open Targets ENSG00000135503
PharmGKB PA24493
Pharos P36896 (Tchem)
Reactome R-HSA-1181150 (Signaling by NODAL.)
R-HSA-1433617 (Regulation of signaling by NODAL.)
R-HSA-1502540 (Signaling by Activin.)
UniProt B7Z5L8 B7Z5W5 P36896 Q15479 Q15480 Q15481 Q15482

Target Cross References - Domain

InterPro IPR000333 (TGFB_receptor.)
IPR000472 (Activin_recp.)
IPR000719 (Prot_kinase_dom.)
IPR003605 (GS_dom.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR011009 (Kinase-like_dom_sf.)
IPR017441 (Protein_kinase_ATP_BS.)
Pfam PF00069 (Pkinase)
PF01064 (Activin_recp)
PF08515 (TGF_beta_GS)