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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL5302
Target Type SINGLE PROTEIN
Preferred Name Niemann-Pick C1-like 1 protein
Synonyms NPC1 like intracellular cholesterol transporter 1 | NPC1L1 | Niemann-Pick C1-like 1 protein
Organism Macaca mulatta
Species Group No
Protein Target Classification
  • transporter

Target Components

Component Description Relationship Accession
NPC1 like intracellular cholesterol transporter 1 SINGLE PROTEIN A0MJA5

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0044214 (spanning component of plasma membrane)
GO Molecular Function GO:0005319 (lipid transporter activity)
GO:0017137 (Rab GTPase binding)
GO:0031489 (myosin V binding)
GO Biological Process GO:0006695 (cholesterol biosynthetic process)
GO:0030299 (intestinal cholesterol absorption)
GO:0030301 (cholesterol transport)
GO:0042157 (lipoprotein metabolic process)
GO:0071501 (cellular response to sterol depletion)

Target Cross References - Protein

canSAR A0MJA5
UniProt A0MJA5 F6RBH5

Target Cross References - Domain

InterPro IPR000731 (SSD.)
IPR003392 (Ptc/Disp.)
IPR004765 (NP_C_type.)
IPR032190 (NPC1_N.)
Pfam PF02460 (Patched)
PF12349 (Sterol-sensing)
PF16414 (NPC1_N)
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