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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL5301
Target Type SINGLE PROTEIN
Preferred Name Niemann-Pick C1-like 1 protein
Synonyms NPC1L1 | Niemann-Pick C1-like 1 protein
Organism Canis lupus familiaris
Species Group No
Protein Target Classification
  • unclassified protein

Target Components

Component Description Relationship Accession
Niemann-Pick C1-like 1 protein SINGLE PROTEIN A0MJA4

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005886 (plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO Molecular Function GO:0005319 (lipid transporter activity)
GO:0017127 (cholesterol transporter activity)
GO Biological Process GO:0015918 (sterol transport)
GO:0030301 (cholesterol transport)

Target Cross References - Protein

canSAR A0MJA4
Reactome R-CFA-265473 (Trafficking of dietary sterols.)
UniProt A0MJA4

Target Cross References - Domain

InterPro IPR000731 (SSD.)
IPR003392 (Ptc/Disp.)
IPR004765 (NP_C_type.)
IPR032190 (NPC1_N.)
Pfam PF02460 (Patched)
PF12349 (Sterol-sensing)
PF16414 (NPC1_N)
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