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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL5222
Target Type SINGLE PROTEIN
Preferred Name Tyrosine-protein kinase ABL2
Synonyms Abelson murine leukemia viral oncogene homolog 2 | Abelson tyrosine-protein kinase 2 | Abelson-related gene protein | Abl2 | Arg | Tyrosine-protein kinase ARG
Organism Mus musculus
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > tk protein kinase group > tyrosine protein kinase abl family

Target Components

Component Description Relationship Accession
Abelson tyrosine-protein kinase 2 SINGLE PROTEIN Q4JIM5

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0001891 (phagocytic cup)
GO:0005737 (cytoplasm)
GO:0005856 (cytoskeleton)
GO:0015629 (actin cytoskeleton)
GO:0016023 (cytoplasmic, membrane-bounded vesicle)
GO:0030027 (lamellipodium)
GO:0031234 (extrinsic component of cytoplasmic side of plasma membrane)
GO:0043197 (dendritic spine)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0000287 (magnesium ion binding)
GO:0004672 (protein kinase activity)
GO:0004713 (protein tyrosine kinase activity)
GO:0004715 (non-membrane spanning protein tyrosine kinase activity)
GO:0005102 (receptor binding)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0030145 (manganese ion binding)
GO:0046872 (metal ion binding)
GO Biological Process GO:0006468 (protein phosphorylation)
GO:0006909 (phagocytosis)
GO:0006930 (substrate-dependent cell migration, cell extension)
GO:0007015 (actin filament organization)
GO:0007155 (cell adhesion)
GO:0007173 (epidermal growth factor receptor signaling pathway)
GO:0007204 (positive regulation of cytosolic calcium ion concentration)
GO:0007612 (learning)
GO:0008542 (visual learning)
GO:0010506 (regulation of autophagy)
GO:0010863 (positive regulation of phospholipase C activity)
GO:0010976 (positive regulation of neuron projection development)
GO:0016310 (phosphorylation)
GO:0016322 (neuron remodeling)
GO:0016477 (cell migration)
GO:0018108 (peptidyl-tyrosine phosphorylation)
GO:0021587 (cerebellum morphogenesis)
GO:0022408 (negative regulation of cell-cell adhesion)
GO:0030036 (actin cytoskeleton organization)
GO:0030100 (regulation of endocytosis)
GO:0030155 (regulation of cell adhesion)
GO:0032092 (positive regulation of protein binding)
GO:0034613 (cellular protein localization)
GO:0035024 (negative regulation of Rho protein signal transduction)
GO:0035640 (exploration behavior)
GO:0038083 (peptidyl-tyrosine autophosphorylation)
GO:0042127 (regulation of cell proliferation)
GO:0043123 (positive regulation of I-kappaB kinase/NF-kappaB signaling)
GO:0045087 (innate immune response)
GO:0046632 (alpha-beta T cell differentiation)
GO:0048008 (platelet-derived growth factor receptor signaling pathway)
GO:0048813 (dendrite morphogenesis)
GO:0050885 (neuromuscular process controlling balance)
GO:0051017 (actin filament bundle assembly)
GO:0051353 (positive regulation of oxidoreductase activity)
GO:0060020 (Bergmann glial cell differentiation)
GO:0070374 (positive regulation of ERK1 and ERK2 cascade)
GO:0071300 (cellular response to retinoic acid)
GO:0097062 (dendritic spine maintenance)
GO:1900042 (positive regulation of interleukin-2 secretion)
GO:1902715 (positive regulation of interferon-gamma secretion)
GO:1903053 (regulation of extracellular matrix organization)
GO:2000096 (positive regulation of Wnt signaling pathway, planar cell polarity pathway)
GO:2000352 (negative regulation of endothelial cell apoptotic process)

Target Cross References - Protein

canSAR Q4JIM5
IntAct Q4JIM5
UniProt Q4JIM5

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR000980 (SH2.)
IPR001245 (Ser-Thr/Tyr_kinase_cat_dom.)
IPR001452 (SH3_domain.)
IPR008266 (Tyr_kinase_AS.)
IPR011009 (Kinase-like_dom.)
IPR015015 (F-actin_binding.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR020635 (Tyr_kinase_cat_dom.)
IPR033217 (ABL2.)
Pfam PF00017 (SH2)
PF00018 (SH3_1)
PF07714 (Pkinase_Tyr)
PF08919 (F_actin_bind)

Target Cross References - Structure

PDBe 4XLI
CREDO 4XLI
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