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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL5202
Preferred Name Sodium channel protein type VIII alpha subunit
Synonyms MED | SCN8A | Sodium channel protein type 8 subunit alpha | Sodium channel protein type VIII subunit alpha | Voltage-gated sodium channel subunit alpha Nav1.6
Organism Homo sapiens
Species Group No
Protein Target Classification
  • ion channel > voltage-gated ion channel > voltage-gated sodium channel

Target Components

Component Description Relationship Accession
Sodium channel protein type 8 subunit alpha SINGLE PROTEIN Q9UQD0

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2331043 Sodium channel alpha subunit PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000196876
Ensembl ENSG00000196876
GO Cellular Component GO:0001518 (voltage-gated sodium channel complex)
GO:0005886 (plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0030018 (Z disc)
GO:0031410 (cytoplasmic vesicle)
GO:0033268 (node of Ranvier)
GO:0043194 (axon initial segment)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0005216 (ion channel activity)
GO:0005244 (voltage-gated ion channel activity)
GO:0005248 (voltage-gated sodium channel activity)
GO:0005272 (sodium channel activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO Biological Process GO:0006811 (ion transport)
GO:0006814 (sodium ion transport)
GO:0007399 (nervous system development)
GO:0007422 (peripheral nervous system development)
GO:0019228 (neuronal action potential)
GO:0034220 (ion transmembrane transport)
GO:0034765 (regulation of ion transmembrane transport)
GO:0035725 (sodium ion transmembrane transport)
GO:0042552 (myelination)
GO:0055085 (transmembrane transport)
GO:0086010 (membrane depolarization during action potential)
Wikipedia SCN8A

Target Cross References - Protein

CGD Cognitive impairment with or without cerebellar ataxia; Epileptic encephalopathy, early infantile, 13
Human Protein Atlas ENSG00000196876
IntAct Q9UQD0
Guide to Pharmacology 583
Open Targets ENSG00000196876
PharmGKB PA35009
Pharos Q9UQD0 (Tclin)
Reactome R-HSA-445095 (Interaction between L1 and Ankyrins.)
R-HSA-5576892 (Phase 0 - rapid depolarisation.)
UniProt B9VWG8 O95788 Q9NYX2 Q9UPB2 Q9UQD0

Target Cross References - Domain

InterPro IPR000048 (IQ_motif_EF-hand-BS.)
IPR001696 (Na_channel_asu.)
IPR005821 (Ion_trans_dom.)
IPR008054 (Na_channel_a8su.)
IPR010526 (Na_trans_assoc.)
IPR024583 (Na_trans_cytopl.)
IPR027359 (Volt_channel_dom_sf.)
Pfam PF00520 (Ion_trans)
PF00612 (IQ)
PF06512 (Na_trans_assoc)
PF11933 (Na_trans_cytopl)