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Target Report Card

Target Name and Classification

Target ID CHEMBL5175
Preferred Name Casein kinase I delta
Synonyms CKI-delta | CKId | Casein kinase I isoform delta | Csnk1d | Hckid | Tau-protein kinase CSNK1D
Organism Mus musculus
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > ck1 protein kinase group > ck1 protein kinase ck1 family

Target Components

Component Description Relationship Accession
Casein kinase I isoform delta SINGLE PROTEIN Q9DC28

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO:0005794 (Golgi apparatus)
GO:0005813 (centrosome)
GO:0005815 (microtubule organizing center)
GO:0005819 (spindle)
GO:0005829 (cytosol)
GO:0005856 (cytoskeleton)
GO:0005876 (spindle microtubule)
GO:0005886 (plasma membrane)
GO:0016020 (membrane)
GO:0043005 (neuron projection)
GO:0048471 (perinuclear region of cytoplasm)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0042277 (peptide binding)
GO:0045296 (cadherin binding)
GO:0050321 (tau-protein kinase activity)
GO Biological Process GO:0001934 (positive regulation of protein phosphorylation)
GO:0006468 (protein phosphorylation)
GO:0006897 (endocytosis)
GO:0007020 (microtubule nucleation)
GO:0007030 (Golgi organization)
GO:0007623 (circadian rhythm)
GO:0008360 (regulation of cell shape)
GO:0016055 (Wnt signaling pathway)
GO:0016310 (phosphorylation)
GO:0018105 (peptidyl-serine phosphorylation)
GO:0030177 (positive regulation of Wnt signaling pathway)
GO:0032436 (positive regulation of proteasomal ubiquitin-dependent protein catabolic process)
GO:0032922 (circadian regulation of gene expression)
GO:0034067 (protein localization to Golgi apparatus)
GO:0042752 (regulation of circadian rhythm)
GO:0048511 (rhythmic process)
GO:0051225 (spindle assembly)
GO:0061512 (protein localization to cilium)
GO:0071539 (protein localization to centrosome)
GO:0090263 (positive regulation of canonical Wnt signaling pathway)
GO:1905426 (positive regulation of Wnt-mediated midbrain dopaminergic neuron differentiation)
GO:1905515 (non-motile cilium assembly)
GO:1990090 (cellular response to nerve growth factor stimulus)
GO:2000052 (positive regulation of non-canonical Wnt signaling pathway)

Target Cross References - Protein

canSAR Q9DC28
IntAct Q9DC28
Reactome R-MMU-204005 (COPII (Coat Protein 2) Mediated Vesicle Transport.)
R-MMU-2565942 (Regulation of PLK1 Activity at G2/M Transition.)
R-MMU-380259 (Loss of Nlp from mitotic centrosomes.)
R-MMU-380270 (Recruitment of mitotic centrosome proteins and complexes.)
R-MMU-380320 (Recruitment of NuMA to mitotic centrosomes.)
R-MMU-508751 (Circadian Clock.)
R-MMU-5620912 (Anchoring of the basal body to the plasma membrane.)
R-MMU-8854518 (AURKA Activation by TPX2.)
UniProt Q3TZK2 Q99KK4 Q9DC28

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR011009 (Kinase-like_dom_sf.)
IPR017441 (Protein_kinase_ATP_BS.)
Pfam PF00069 (Pkinase)

Target Cross References - Structure

PDBe 4JJR 5X17