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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL5163
Target Type SINGLE PROTEIN
Preferred Name Sodium channel protein type III alpha subunit
Synonyms KIAA1356 | NAC3 | SCN3A | Sodium channel protein brain III subunit alpha | Sodium channel protein type 3 subunit alpha | Sodium channel protein type III subunit alpha | Voltage-gated sodium channel subtype III | Voltage-gated sodium channel subunit alpha Nav1.3
Organism Homo sapiens
Species Group No
Protein Target Classification
  • ion channel > voltage-gated ion channel > voltage-gated sodium channel

Target Components

Component Description Relationship Accession
Sodium channel protein type 3 subunit alpha SINGLE PROTEIN Q9NY46

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2096682 Sodium channel alpha subunits; brain (Types I, II, III) PROTEIN FAMILY
CHEMBL2331043 Sodium channel alpha subunit PROTEIN FAMILY

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL29919 ELPETRIGINE Sodium channel protein type III alpha subunit blocker 0 PubMed PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000153253
Ensembl ENSG00000153253
GO Cellular Component GO:0001518 (voltage-gated sodium channel complex)
GO:0005737 (cytoplasm)
GO:0005886 (plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO Molecular Function GO:0005216 (ion channel activity)
GO:0005244 (voltage-gated ion channel activity)
GO:0005248 (voltage-gated sodium channel activity)
GO:0005272 (sodium channel activity)
GO Biological Process GO:0006811 (ion transport)
GO:0006814 (sodium ion transport)
GO:0019228 (neuronal action potential)
GO:0034220 (ion transmembrane transport)
GO:0034765 (regulation of ion transmembrane transport)
GO:0035725 (sodium ion transmembrane transport)
GO:0055085 (transmembrane transport)
GO:0086010 (membrane depolarization during action potential)
Wikipedia SCN3A

Target Cross References - Protein

canSAR Q9NY46
Human Protein Atlas ENSG00000153253
IntAct Q9NY46
Guide to Pharmacology 580
Open Targets ENSG00000153253
PharmGKB PA35005
Pharos Q9NY46 (Tclin)
Reactome R-HSA-445095 (Interaction between L1 and Ankyrins.)
R-HSA-5576892 (Phase 0 - rapid depolarisation.)
UniProt Q16142 Q53SX0 Q9BZB3 Q9C006 Q9NY46 Q9NYK2 Q9P2J1 Q9UPD1 Q9Y6P4

Target Cross References - Domain

InterPro IPR000048 (IQ_motif_EF-hand-BS.)
IPR001696 (Na_channel_asu.)
IPR005821 (Ion_trans_dom.)
IPR010526 (Na_trans_assoc.)
IPR024583 (Na_trans_cytopl.)
IPR027359 (Volt_channel_dom_sf.)
Pfam PF00520 (Ion_trans)
PF06512 (Na_trans_assoc)
PF11933 (Na_trans_cytopl)
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