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Target Report Card

Target Name and Classification

Target ID CHEMBL5148
Preferred Name Casein kinase I alpha
Synonyms CK1 | CKI-alpha | Casein kinase I isoform alpha | Csnk1a1
Organism Mus musculus
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > ck1 protein kinase group > ck1 protein kinase ck1 family

Target Components

Component Description Relationship Accession
Casein kinase I isoform alpha SINGLE PROTEIN Q8BK63

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0000775 (chromosome, centromeric region)
GO:0000776 (kinetochore)
GO:0000777 (condensed chromosome kinetochore)
GO:0005634 (nucleus)
GO:0005694 (chromosome)
GO:0005737 (cytoplasm)
GO:0005813 (centrosome)
GO:0005815 (microtubule organizing center)
GO:0005829 (cytosol)
GO:0005847 (mRNA cleavage and polyadenylation specificity factor complex)
GO:0005856 (cytoskeleton)
GO:0005929 (cilium)
GO:0016607 (nuclear speck)
GO:0030877 (beta-catenin destruction complex)
GO:0036064 (ciliary basal body)
GO:0042995 (cell projection)
GO:0045095 (keratin filament)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0000287 (magnesium ion binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0042277 (peptide binding)
GO:0051219 (phosphoprotein binding)
GO Biological Process GO:0000902 (cell morphogenesis)
GO:0006468 (protein phosphorylation)
GO:0006909 (phagocytosis)
GO:0007030 (Golgi organization)
GO:0007049 (cell cycle)
GO:0008360 (regulation of cell shape)
GO:0016055 (Wnt signaling pathway)
GO:0016310 (phosphorylation)
GO:0018105 (peptidyl-serine phosphorylation)
GO:0032436 (positive regulation of proteasomal ubiquitin-dependent protein catabolic process)
GO:0045104 (intermediate filament cytoskeleton organization)
GO:0051301 (cell division)
GO:0090090 (negative regulation of canonical Wnt signaling pathway)
GO:1904424 (regulation of GTP binding)

Target Cross References - Protein

canSAR Q8BK63
IntAct Q8BK63
Reactome R-MMU-195253 (Degradation of beta-catenin by the destruction complex.)
R-MMU-196299 (Beta-catenin phosphorylation cascade.)
R-MMU-4641262 (Disassembly of the destruction complex and recruitment of AXIN to the membrane.)
R-MMU-5610785 (GLI3 is processed to GLI3R by the proteasome.)
R-MMU-5635838 (Activation of SMO.)
UniProt Q3UIL0 Q64506 Q80XI2 Q8BK63 Q99LY3

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR011009 (Kinase-like_dom_sf.)
IPR017441 (Protein_kinase_ATP_BS.)
Pfam PF00069 (Pkinase)