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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL5146
Target Type SINGLE PROTEIN
Preferred Name Breakpoint cluster region protein
Synonyms BCR | BCR1 | Breakpoint cluster region protein | D22S11 | Renal carcinoma antigen NY-REN-26
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > atypical protein kinase group > atypical protein kinase bcr family
  • other cytosolic protein

Target Components

Component Description Relationship Accession
Breakpoint cluster region protein SINGLE PROTEIN P11274

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2096618 Bcr/Abl fusion protein CHIMERIC PROTEIN

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL2105708 PONATINIB HYDROCHLORIDE Breakpoint cluster region protein inhibitor 4 DailyMed PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000186716
Ensembl ENSG00000186716
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0005886 (plasma membrane)
GO:0014069 (postsynaptic density)
GO:0016020 (membrane)
GO:0030054 (cell junction)
GO:0043234 (protein complex)
GO:0045202 (synapse)
GO:0045211 (postsynaptic membrane)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004674 (protein serine/threonine kinase activity)
GO:0004713 (protein tyrosine kinase activity)
GO:0005085 (guanyl-nucleotide exchange factor activity)
GO:0005089 (Rho guanyl-nucleotide exchange factor activity)
GO:0005096 (GTPase activator activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0019899 (enzyme binding)
GO Biological Process GO:0002692 (negative regulation of cellular extravasation)
GO:0006468 (protein phosphorylation)
GO:0007165 (signal transduction)
GO:0007420 (brain development)
GO:0016310 (phosphorylation)
GO:0018108 (peptidyl-tyrosine phosphorylation)
GO:0030036 (actin cytoskeleton organization)
GO:0030336 (negative regulation of cell migration)
GO:0032496 (response to lipopolysaccharide)
GO:0035023 (regulation of Rho protein signal transduction)
GO:0035556 (intracellular signal transduction)
GO:0042472 (inner ear morphogenesis)
GO:0043114 (regulation of vascular permeability)
GO:0043314 (negative regulation of neutrophil degranulation)
GO:0043547 (positive regulation of GTPase activity)
GO:0046777 (protein autophosphorylation)
GO:0048008 (platelet-derived growth factor receptor signaling pathway)
GO:0050728 (negative regulation of inflammatory response)
GO:0050766 (positive regulation of phagocytosis)
GO:0050885 (neuromuscular process controlling balance)
GO:0051056 (regulation of small GTPase mediated signal transduction)
GO:0051726 (regulation of cell cycle)
GO:0060313 (negative regulation of blood vessel remodeling)
Wikipedia BCR_gene

Target Cross References - Protein

canSAR P11274
CGD CML treatment, response to
Human Protein Atlas ENSG00000186716
IntAct P11274
Open Targets ENSG00000186716
PharmGKB PA25321
Reactome R-HSA-1839117 (Signaling by cytosolic FGFR1 fusion mutants.)
R-HSA-194840 (Rho GTPase cycle.)
R-HSA-5655302 (Signaling by FGFR1 in disease.)
UniProt P11274 P78501 Q12842 Q4LE80 Q6NZI3

Target Cross References - Domain

InterPro IPR000008 (C2_dom.)
IPR000198 (RhoGAP_dom.)
IPR000219 (DH-domain.)
IPR001331 (GDS_CDC24_CS.)
IPR001849 (PH_domain.)
IPR008936 (Rho_GTPase_activation_prot.)
IPR011993 (PH_dom-like.)
IPR015123 (Bcr-Abl_oncoprot_oligo.)
Pfam PF00168 (C2)
PF00620 (RhoGAP)
PF00621 (RhoGEF)
PF09036 (Bcr-Abl_Oligo)

Target Cross References - Structure

PDBe 1K1F
CREDO 1K1F
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