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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL5137
Target Type SINGLE PROTEIN
Preferred Name Metabotropic glutamate receptor 2
Synonyms GPRC1B | GRM2 | MGLUR2 | Metabotropic glutamate receptor 2 | mGluR2
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor > family c g protein-coupled receptor > small molecule receptor (family c gpcr) > neurotransmitter receptor (family c gpcr) > metabotropic glutamate receptor

Target Components

Component Description Relationship Accession
Metabotropic glutamate receptor 2 SINGLE PROTEIN Q14416

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL2110730 POMAGLUMETAD METHIONIL Metabotropic glutamate receptor 2 agonist 3 PubMed PubMed
CHEMBL3301593 DECOGLURANT Metabotropic glutamate receptor 2 modulator 2
CHEMBL375611 LY404039 Metabotropic glutamate receptor 2 agonist 1 PubMed
CHEMBL3544939 LY2979165 Metabotropic glutamate receptor 2 agonist 1 Other
CHEMBL3545270 LY2969822 Metabotropic glutamate receptor 2 agonist 1 Other

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000164082
Ensembl ENSG00000164082
GO Cellular Component GO:0005622 (intracellular)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0030054 (cell junction)
GO:0030424 (axon)
GO:0030425 (dendrite)
GO:0042734 (presynaptic membrane)
GO:0042995 (cell projection)
GO:0043005 (neuron projection)
GO:0045202 (synapse)
GO Molecular Function GO:0001641 (group II metabotropic glutamate receptor activity)
GO:0004871 (signal transducer activity)
GO:0004930 (G-protein coupled receptor activity)
GO:0005246 (calcium channel regulator activity)
GO:0005515 (protein binding)
GO:0008066 (glutamate receptor activity)
GO Biological Process GO:0007165 (signal transduction)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007194 (negative regulation of adenylate cyclase activity)
GO:0007196 (adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway)
GO:0007216 (G-protein coupled glutamate receptor signaling pathway)
GO:0007268 (chemical synaptic transmission)
GO:0014047 (glutamate secretion)
GO:0051966 (regulation of synaptic transmission, glutamatergic)
Wikipedia Metabotropic_glutamate_receptor_2

Target Cross References - Protein

canSAR Q14416
Human Protein Atlas ENSG00000164082
IntAct Q14416
Guide to Pharmacology 290
Open Targets ENSG00000164082
PharmGKB PA28991
Pharos Q14416 (Tchem)
Reactome R-HSA-418594 (G alpha (i) signalling events.)
R-HSA-420499 (Class C/3 (Metabotropic glutamate/pheromone receptors).)
UniProt B0M0K7 Q14416 Q14CU5 Q52MC6 Q9H3N6

Target Cross References - Domain

InterPro IPR000162 (GPCR_3_mtglu_rcpt.)
IPR000337 (GPCR_3.)
IPR001458 (GPCR_3_mtglu_rcpt_2.)
IPR001828 (ANF_lig-bd_rcpt.)
IPR011500 (GPCR_3_9-Cys_dom.)
IPR017978 (GPCR_3_C.)
IPR017979 (GPCR_3_CS.)
IPR028082 (Peripla_BP_I.)
Pfam PF00003 (7tm_3)
PF01094 (ANF_receptor)
PF07562 (NCD3G)

Target Cross References - Structure

PDBe 4XAQ 4XAS 5CNI 5CNJ 5KZN 5KZQ
CREDO 4XAQ 4XAS 5CNI 5CNJ 5KZN 5KZQ
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