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Target Report Card

Target Name and Classification

Target ID CHEMBL5134
Preferred Name Voltage-gated T-type calcium channel alpha-1H subunit
Synonyms Cacna1h | Voltage-dependent T-type calcium channel subunit alpha-1H | Voltage-gated calcium channel subunit alpha Cav3.2
Organism Rattus norvegicus
Species Group No
Protein Target Classification
  • ion channel > voltage-gated ion channel > voltage-gated calcium channel

Target Components

Component Description Relationship Accession
Voltage-dependent T-type calcium channel subunit alpha-1H SINGLE PROTEIN Q9EQ60

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005634 (nucleus)
GO:0005737 (cytoplasm)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0005891 (voltage-gated calcium channel complex)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0030425 (dendrite)
GO:0043204 (perikaryon)
GO Molecular Function GO:0005216 (ion channel activity)
GO:0005244 (voltage-gated ion channel activity)
GO:0005245 (voltage-gated calcium channel activity)
GO:0005248 (voltage-gated sodium channel activity)
GO:0005262 (calcium channel activity)
GO:0008332 (low voltage-gated calcium channel activity)
GO:0046872 (metal ion binding)
GO Biological Process GO:0006811 (ion transport)
GO:0006816 (calcium ion transport)
GO:0019228 (neuronal action potential)
GO:0019233 (sensory perception of pain)
GO:0032342 (aldosterone biosynthetic process)
GO:0034651 (cortisol biosynthetic process)
GO:0034765 (regulation of ion transmembrane transport)
GO:0035725 (sodium ion transmembrane transport)
GO:0045956 (positive regulation of calcium ion-dependent exocytosis)
GO:0055085 (transmembrane transport)
GO:0070509 (calcium ion import)
GO:0070588 (calcium ion transmembrane transport)
GO:0086010 (membrane depolarization during action potential)

Target Cross References - Protein

canSAR Q9EQ60
Guide to Pharmacology 536
UniProt Q9EQ60

Target Cross References - Domain

InterPro IPR005445 (VDCC_T_a1.)
IPR005821 (Ion_trans_dom.)
IPR027359 (Volt_channel_dom_sf.)
Pfam PF00520 (Ion_trans)