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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL5122
Preferred Name Discoidin domain-containing receptor 2
Synonyms CD167 antigen-like family member B | CD_antigen=CD167b | DDR2 | Discoidin domain receptor 2 | Discoidin domain-containing receptor 2 | Discoidin domain-containing receptor tyrosine kinase 2 | NTRKR3 | Neurotrophic tyrosine kinase, receptor-related 3 | Receptor protein-tyrosine kinase TKT | TKT | TYRO10 | Tyrosine-protein kinase TYRO10
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > tk protein kinase group > tyrosine protein kinase ddr family

Target Components

Component Description Relationship Accession
Discoidin domain-containing receptor 2 SINGLE PROTEIN Q16832

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL1946170 REGORAFENIB Discoidin domain-containing receptor 2 inhibitor 4 Expert

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000162733
Ensembl ENSG00000162733
GO Cellular Component GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0005925 (focal adhesion)
GO:0015629 (actin cytoskeleton)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0016324 (apical plasma membrane)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004713 (protein tyrosine kinase activity)
GO:0004714 (transmembrane receptor protein tyrosine kinase activity)
GO:0005515 (protein binding)
GO:0005518 (collagen binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0038062 (protein tyrosine kinase collagen receptor activity)
GO Biological Process GO:0001503 (ossification)
GO:0003416 (endochondral bone growth)
GO:0006468 (protein phosphorylation)
GO:0007155 (cell adhesion)
GO:0007165 (signal transduction)
GO:0007169 (transmembrane receptor protein tyrosine kinase signaling pathway)
GO:0008284 (positive regulation of cell proliferation)
GO:0010715 (regulation of extracellular matrix disassembly)
GO:0010763 (positive regulation of fibroblast migration)
GO:0016310 (phosphorylation)
GO:0018108 (peptidyl-tyrosine phosphorylation)
GO:0030198 (extracellular matrix organization)
GO:0030199 (collagen fibril organization)
GO:0030500 (regulation of bone mineralization)
GO:0031214 (biomineral tissue development)
GO:0035988 (chondrocyte proliferation)
GO:0038063 (collagen-activated tyrosine kinase receptor signaling pathway)
GO:0045669 (positive regulation of osteoblast differentiation)
GO:0045860 (positive regulation of protein kinase activity)
GO:0046777 (protein autophosphorylation)
GO:0048146 (positive regulation of fibroblast proliferation)
GO:0051091 (positive regulation of sequence-specific DNA binding transcription factor activity)
GO:0090091 (positive regulation of extracellular matrix disassembly)
Wikipedia Discoidin_domain-containing_receptor_2

Target Cross References - Protein

canSAR Q16832
CGD Spondylometaepiphyseal dysplasia, short limb-hand type
Human Protein Atlas ENSG00000162733
IntAct Q16832
Guide to Pharmacology 1844
Open Targets ENSG00000162733
PharmGKB PA27196
Pharos Q16832 (Tchem)
Reactome R-HSA-3000171 (Non-integrin membrane-ECM interactions.)
UniProt Q16832 Q7Z730

Target Cross References - Domain

InterPro IPR000421 (FA58C.)
IPR000719 (Prot_kinase_dom.)
IPR001245 (Ser-Thr/Tyr_kinase_cat_dom.)
IPR002011 (Tyr_kinase_rcpt_2_CS.)
IPR008266 (Tyr_kinase_AS.)
IPR008979 (Galactose-bd-like_sf.)
IPR011009 (Kinase-like_dom_sf.)
IPR020635 (Tyr_kinase_cat_dom.)
IPR034299 (DDR2.)
Pfam PF00754 (F5_F8_type_C)
PF07714 (Pkinase_Tyr)

Target Cross References - Structure