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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL5112
Preferred Name GABA receptor alpha-5 subunit
Synonyms GABA(A) receptor subunit alpha-5 | GABRA5 | Gamma-aminobutyric acid receptor subunit alpha-5
Organism Homo sapiens
Species Group No
Protein Target Classification
  • ion channel > ligand-gated ion channel > gaba-a receptor

Target Components

Component Description Relationship Accession
Gamma-aminobutyric acid receptor subunit alpha-5 SINGLE PROTEIN P31644

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3885577 Gamma-aminobutyric acid receptor subunit alpha-5/beta-3/gamma-3 PROTEIN COMPLEX
CHEMBL3885576 Gamma-aminobutyric acid receptor subunit alpha-5/beta-2 PROTEIN COMPLEX
CHEMBL2093872 GABA-A receptor; anion channel PROTEIN COMPLEX GROUP
CHEMBL2094122 GABA-A receptor; alpha-5/beta-3/gamma-2 PROTEIN COMPLEX
CHEMBL2109244 GABA-A receptor; agonist GABA site PROTEIN COMPLEX GROUP
CHEMBL2109243 GABA-A receptor; benzodiazepine site PROTEIN COMPLEX GROUP

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000186297
Ensembl ENSG00000186297
GO Cellular Component GO:0005654 (nucleoplasm)
GO:0005829 (cytosol)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0030054 (cell junction)
GO:0030425 (dendrite)
GO:0032809 (neuronal cell body membrane)
GO:0034707 (chloride channel complex)
GO:0043235 (receptor complex)
GO:0044297 (cell body)
GO:0045202 (synapse)
GO:0045211 (postsynaptic membrane)
GO:1902711 (GABA-A receptor complex)
GO Molecular Function GO:0004888 (transmembrane signaling receptor activity)
GO:0004890 (GABA-A receptor activity)
GO:0005215 (transporter activity)
GO:0005216 (ion channel activity)
GO:0005230 (extracellular ligand-gated ion channel activity)
GO:0005254 (chloride channel activity)
GO:0038023 (signaling receptor activity)
GO:0050811 (GABA receptor binding)
GO Biological Process GO:0001662 (behavioral fear response)
GO:0006811 (ion transport)
GO:0006821 (chloride transport)
GO:0007165 (signal transduction)
GO:0007214 (gamma-aminobutyric acid signaling pathway)
GO:0007268 (chemical synaptic transmission)
GO:0007420 (brain development)
GO:0007605 (sensory perception of sound)
GO:0008306 (associative learning)
GO:0034220 (ion transmembrane transport)
GO:0043523 (regulation of neuron apoptotic process)
GO:0043524 (negative regulation of neuron apoptotic process)
GO:0048666 (neuron development)
GO:0060119 (inner ear receptor cell development)
GO:0060384 (innervation)
GO:0090102 (cochlea development)
GO:1902476 (chloride transmembrane transport)
Wikipedia GABRA5

Target Cross References - Protein

canSAR P31644
Human Protein Atlas ENSG00000186297
Guide to Pharmacology 408
Open Targets ENSG00000186297
PharmGKB PA28493
Pharos P31644 (Tclin)
Reactome R-HSA-112314 (Neurotransmitter receptors and postsynaptic signal transmission.)
R-HSA-977441 (GABA A receptor activation.)
UniProt A8K338 P31644 Q14DC2 Q53XL6 Q9NYT3 Q9NYT4 Q9NYT5

Target Cross References - Domain

InterPro IPR001390 (GABAAa_rcpt.)
IPR005435 (GABBAa5_rcpt.)
IPR006028 (GABAA/Glycine_rcpt.)
IPR006029 (Neurotrans-gated_channel_TM.)
IPR006201 (Neur_channel.)
IPR006202 (Neur_chan_lig-bd.)
IPR018000 (Neurotransmitter_ion_chnl_CS.)
IPR036719 (Neuro-gated_channel_TM_sf.)
IPR036734 (Neur_chan_lig-bd_sf.)
Pfam PF02931 (Neur_chan_LBD)
PF02932 (Neur_chan_memb)

Target Cross References - Structure