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Target Report Card

Target Name and Classification

Target ID CHEMBL5102
Target Type SINGLE PROTEIN
Preferred Name Vanilloid receptor
Synonyms Capsaicin receptor | OTRPC1 | Osm-9-like TRP channel 1 | Transient receptor potential cation channel subfamily V member 1 | TrpV1 | Trpv1 | Vanilloid receptor 1 | Vanilloid receptor type 1-like | Vr1 | Vr1l
Organism Rattus norvegicus
Species Group No
Protein Target Classification
  • ion channel > voltage-gated ion channel > transient receptor potential channel

Target Components

Component Description Relationship Accession
Transient receptor potential cation channel subfamily V member 1 SINGLE PROTEIN O35433

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2096684 Vanilloid receptor PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005829 (cytosol)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0009897 (external side of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0030054 (cell junction)
GO:0030425 (dendrite)
GO:0031226 (intrinsic component of plasma membrane)
GO:0032591 (dendritic spine membrane)
GO:0042995 (cell projection)
GO:0043005 (neuron projection)
GO:0043025 (neuronal cell body)
GO:0045202 (synapse)
GO:0045211 (postsynaptic membrane)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004888 (transmembrane signaling receptor activity)
GO:0005216 (ion channel activity)
GO:0005230 (extracellular ligand-gated ion channel activity)
GO:0005231 (excitatory extracellular ligand-gated ion channel activity)
GO:0005261 (cation channel activity)
GO:0005262 (calcium channel activity)
GO:0005515 (protein binding)
GO:0005516 (calmodulin binding)
GO:0005524 (ATP binding)
GO:0008289 (lipid binding)
GO:0008324 (cation transmembrane transporter activity)
GO:0015276 (ligand-gated ion channel activity)
GO:0015278 (calcium-release channel activity)
GO:0017081 (chloride channel regulator activity)
GO:0035091 (phosphatidylinositol binding)
GO:0042802 (identical protein binding)
GO:0046872 (metal ion binding)
GO:0051219 (phosphoprotein binding)
GO:0097603 (temperature-gated ion channel activity)
GO Biological Process GO:0000122 (negative regulation of transcription from RNA polymerase II promoter)
GO:0001659 (temperature homeostasis)
GO:0001660 (fever generation)
GO:0001774 (microglial cell activation)
GO:0002024 (diet induced thermogenesis)
GO:0002790 (peptide secretion)
GO:0006629 (lipid metabolic process)
GO:0006811 (ion transport)
GO:0006816 (calcium ion transport)
GO:0006954 (inflammatory response)
GO:0007165 (signal transduction)
GO:0007204 (positive regulation of cytosolic calcium ion concentration)
GO:0009268 (response to pH)
GO:0009408 (response to heat)
GO:0010243 (response to organonitrogen compound)
GO:0014047 (glutamate secretion)
GO:0014832 (urinary bladder smooth muscle contraction)
GO:0019233 (sensory perception of pain)
GO:0034220 (ion transmembrane transport)
GO:0034605 (cellular response to heat)
GO:0043065 (positive regulation of apoptotic process)
GO:0043434 (response to peptide hormone)
GO:0045429 (positive regulation of nitric oxide biosynthetic process)
GO:0048265 (response to pain)
GO:0048266 (behavioral response to pain)
GO:0050954 (sensory perception of mechanical stimulus)
GO:0050955 (thermoception)
GO:0050960 (detection of temperature stimulus involved in thermoception)
GO:0050965 (detection of temperature stimulus involved in sensory perception of pain)
GO:0050968 (detection of chemical stimulus involved in sensory perception of pain)
GO:0051209 (release of sequestered calcium ion into cytosol)
GO:0051289 (protein homotetramerization)
GO:0055085 (transmembrane transport)
GO:0060079 (excitatory postsynaptic potential)
GO:0060083 (smooth muscle contraction involved in micturition)
GO:0060454 (positive regulation of gastric acid secretion)
GO:0070588 (calcium ion transmembrane transport)
GO:0071312 (cellular response to alkaloid)
GO:0071318 (cellular response to ATP)
GO:0071345 (cellular response to cytokine stimulus)
GO:0071356 (cellular response to tumor necrosis factor)
GO:0071363 (cellular response to growth factor stimulus)
GO:0071468 (cellular response to acidic pH)
GO:0071502 (cellular response to temperature stimulus)
GO:0090212 (negative regulation of establishment of blood-brain barrier)
GO:0098703 (calcium ion import across plasma membrane)
GO:1901594 (response to capsazepine)
GO:1990090 (cellular response to nerve growth factor stimulus)

Target Cross References - Protein

canSAR O35433
IntAct O35433
Guide to Pharmacology 507
Reactome R-RNO-3295583 (TRP channels.)
UniProt O35433 Q920B3 Q920B4 Q9JLM0 Q9JM56 Q9JM57

Target Cross References - Domain

InterPro IPR002110 (Ankyrin_rpt.)
IPR004729 (TRP_channel.)
IPR005821 (Ion_trans_dom.)
IPR008347 (TRPV1-4_channel.)
IPR020683 (Ankyrin_rpt-contain_dom.)
IPR024862 (TRPV.)
IPR024863 (TRPV1.)
IPR036770 (Ankyrin_rpt-contain_sf.)
Pfam PF00520 (Ion_trans)
PF12796 (Ank_2)

Target Cross References - Structure

PDBe 2NYJ 2PNN 3SUI
CREDO 2NYJ 2PNN 3SUI
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