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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL5082
Target Type SINGLE PROTEIN
Preferred Name Serine/threonine-protein kinase 24
Synonyms MST-3 | MST3 | MST3/C | MST3/N | Mammalian STE20-like protein kinase 3 C-terminal | Mammalian STE20-like protein kinase 3 N-terminal | Mammalian STE20-like protein kinase 3 | STE20-like kinase MST3 | STK24 | STK3 | Serine/threonine-protein kinase 24 12 kDa subunit | Serine/threonine-protein kinase 24 36 kDa subunit | Serine/threonine-protein kinase 24
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > ste protein kinase group > ste protein kinase ste20 family > ste protein kinase ysk subfamily

Target Components

Component Description Relationship Accession
Serine/threonine-protein kinase 24 SINGLE PROTEIN Q9Y6E0

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000102572
Ensembl ENSG00000102572
GO Cellular Component GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005730 (nucleolus)
GO:0005737 (cytoplasm)
GO:0005794 (Golgi apparatus)
GO:0005829 (cytosol)
GO:0016020 (membrane)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0008349 (MAP kinase kinase kinase kinase activity)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0045296 (cadherin binding)
GO:0046872 (metal ion binding)
GO Biological Process GO:0000165 (MAPK cascade)
GO:0000185 (activation of MAPKKK activity)
GO:0006468 (protein phosphorylation)
GO:0006915 (apoptotic process)
GO:0007165 (signal transduction)
GO:0007346 (regulation of mitotic cell cycle)
GO:0008631 (intrinsic apoptotic signaling pathway in response to oxidative stress)
GO:0009267 (cellular response to starvation)
GO:0016310 (phosphorylation)
GO:0030336 (negative regulation of cell migration)
GO:0031098 (stress-activated protein kinase signaling cascade)
GO:0042542 (response to hydrogen peroxide)
GO:0042981 (regulation of apoptotic process)
GO:0046777 (protein autophosphorylation)
GO:0048679 (regulation of axon regeneration)
GO:0048812 (neuron projection morphogenesis)
GO:0097194 (execution phase of apoptosis)
Wikipedia STK24

Target Cross References - Protein

canSAR Q9Y6E0
Human Protein Atlas ENSG00000102572
IntAct Q9Y6E0
Guide to Pharmacology 2217
Open Targets ENSG00000102572
PharmGKB PA36210
Pharos Q9Y6E0 (Tchem)
Reactome R-HSA-111465 (Apoptotic cleavage of cellular proteins.)
R-HSA-75153 (Apoptotic execution phase.)
UniProt O14840 Q5JV92 Q9Y6E0

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR011009 (Kinase-like_dom_sf.)
IPR017441 (Protein_kinase_ATP_BS.)
Pfam PF00069 (Pkinase)

Target Cross References - Structure

PDBe 3A7F 3A7G 3A7H 3A7I 3A7J 3CKW 3CKX 3ZHP 4O27 4QML 4QMM 4QMN 4QMO 4QMP 4QMQ 4QMS 4QMT 4QMU 4QMV 4QMW 4QMX 4QMY 4QMZ 4QNA More...
CREDO 3A7F 3A7G 3A7H 3A7I 3A7J 3CKW 3CKX 3ZHP 4O27 4QML 4QMM 4QMN 4QMO 4QMP 4QMQ 4QMS 4QMT 4QMU 4QMV 4QMW 4QMX 4QMY 4QMZ 4QNA More...
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