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Target Report Card

Target Name and Classification

Target ID CHEMBL5081
Preferred Name Interleukin-1 receptor-associated kinase 3
Synonyms IL-1 receptor-associated kinase M | IRAK-3 | IRAK-M | IRAK3 | Interleukin-1 receptor-associated kinase 3
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > tkl protein kinase group > tkl protein kinase irak family

Target Components

Component Description Relationship Accession
Interleukin-1 receptor-associated kinase 3 SINGLE PROTEIN Q9Y616

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000090376
Ensembl ENSG00000090376
GO Cellular Component GO:0005634 (nucleus)
GO:0005737 (cytoplasm)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0000287 (magnesium ion binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0042803 (protein homodimerization activity)
GO:0046982 (protein heterodimerization activity)
GO Biological Process GO:0001960 (negative regulation of cytokine-mediated signaling pathway)
GO:0002755 (MyD88-dependent toll-like receptor signaling pathway)
GO:0006468 (protein phosphorylation)
GO:0007165 (signal transduction)
GO:0009615 (response to virus)
GO:0010933 (positive regulation of macrophage tolerance induction)
GO:0010936 (negative regulation of macrophage cytokine production)
GO:0016310 (phosphorylation)
GO:0019221 (cytokine-mediated signaling pathway)
GO:0032088 (negative regulation of NF-kappaB transcription factor activity)
GO:0032494 (response to peptidoglycan)
GO:0032496 (response to lipopolysaccharide)
GO:0032695 (negative regulation of interleukin-12 production)
GO:0032715 (negative regulation of interleukin-6 production)
GO:0032720 (negative regulation of tumor necrosis factor production)
GO:0034122 (negative regulation of toll-like receptor signaling pathway)
GO:0042177 (negative regulation of protein catabolic process)
GO:0043242 (negative regulation of protein complex disassembly)
GO:0043244 (regulation of protein complex disassembly)
GO:0043330 (response to exogenous dsRNA)
GO:0043407 (negative regulation of MAP kinase activity)
GO:0045824 (negative regulation of innate immune response)
GO:0046777 (protein autophosphorylation)
GO:0051092 (positive regulation of NF-kappaB transcription factor activity)
GO:0070498 (interleukin-1-mediated signaling pathway)
GO:0070555 (response to interleukin-1)
Wikipedia IRAK3

Target Cross References - Protein

Human Protein Atlas ENSG00000090376
IntAct Q9Y616
Guide to Pharmacology 2044
Open Targets ENSG00000090376
PharmGKB PA38431
Pharos Q9Y616 (Tchem)
Reactome R-HSA-166058 (MyD88:Mal cascade initiated on plasma membrane.)
R-HSA-9020702 (Interleukin-1 signaling.)
UniProt B4DQ57 Q9Y616

Target Cross References - Domain

InterPro IPR000488 (Death_domain.)
IPR000719 (Prot_kinase_dom.)
IPR011009 (Kinase-like_dom_sf.)
IPR011029 (DEATH-like_dom_sf.)
IPR033610 (IRAK3.)
Pfam PF00069 (Pkinase)
PF00531 (Death)