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Target Report Card

Target Name and Classification

Target ID CHEMBL5052
Target Type SINGLE PROTEIN
Preferred Name Serine/threonine-protein kinase MRCK beta
Synonyms CDC42-binding protein kinase beta | CDC42BP-beta | CDC42BPB | DMPK-like beta | MRCK beta | Myotonic dystrophy kinase-related CDC42-binding kinase beta | Myotonic dystrophy protein kinase-like beta | Serine/threonine-protein kinase MRCK beta | Synonyms=KIAA1124
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > agc protein kinase group > agc protein kinase dmpk family > agc protein kinase gek subfamily

Target Components

Component Description Relationship Accession
Serine/threonine-protein kinase MRCK beta SINGLE PROTEIN Q9Y5S2

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000198752
Ensembl ENSG00000198752
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005856 (cytoskeleton)
GO:0005886 (plasma membrane)
GO:0005911 (cell-cell junction)
GO:0016020 (membrane)
GO:0030027 (lamellipodium)
GO:0030054 (cell junction)
GO:0031252 (cell leading edge)
GO:0042641 (actomyosin)
GO:0042995 (cell projection)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0000287 (magnesium ion binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0017048 (Rho GTPase binding)
GO:0044877 (macromolecular complex binding)
GO:0046872 (metal ion binding)
GO Biological Process GO:0006468 (protein phosphorylation)
GO:0007010 (cytoskeleton organization)
GO:0007163 (establishment or maintenance of cell polarity)
GO:0007165 (signal transduction)
GO:0016310 (phosphorylation)
GO:0016477 (cell migration)
GO:0030036 (actin cytoskeleton organization)
GO:0031032 (actomyosin structure organization)
GO:0031532 (actin cytoskeleton reorganization)
GO:0035556 (intracellular signal transduction)

Target Cross References - Protein

canSAR Q9Y5S2
Human Protein Atlas ENSG00000198752
IntAct Q9Y5S2
Guide to Pharmacology 1508
Open Targets ENSG00000198752
PharmGKB PA26268
Pharos Q9Y5S2 (Tbio)
UniProt A9JR72 Q2L7A5 Q86TJ1 Q9ULU5 Q9Y5S2

Target Cross References - Domain

InterPro IPR000095 (CRIB_dom.)
IPR000719 (Prot_kinase_dom.)
IPR000961 (AGC-kinase_C.)
IPR001180 (CNH_dom.)
IPR001849 (PH_domain.)
IPR002219 (PE/DAG-bd.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR011009 (Kinase-like_dom_sf.)
IPR011993 (PH-like_dom_sf.)
IPR014930 (Myotonic_dystrophy_kinase_coil.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR020454 (DAG/PE-bd.)
IPR031597 (KELK.)
IPR033232 (MRCK_beta.)
Pfam PF00069 (Pkinase)
PF00130 (C1_1)
PF00780 (CNH)
PF08826 (DMPK_coil)
PF15796 (KELK)

Target Cross References - Structure

PDBe 3QFV 3TKU 4UAK 4UAL
CREDO 3QFV 3TKU 4UAK 4UAL
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