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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL5047
Target Type SINGLE PROTEIN
Preferred Name Serine/threonine-protein kinase ULK3
Synonyms Serine/threonine-protein kinase ULK3 | ULK3 | Unc-51-like kinase 3
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > other protein kinase group > other protein kinase ulk family

Target Components

Component Description Relationship Accession
Serine/threonine-protein kinase ULK3 SINGLE PROTEIN Q6PHR2

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000140474
Ensembl ENSG00000140474
GO Cellular Component GO:0000407 (pre-autophagosomal structure)
GO:0005737 (cytoplasm)
GO:0097542 (ciliary tip)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO Biological Process GO:0006468 (protein phosphorylation)
GO:0006914 (autophagy)
GO:0016310 (phosphorylation)
GO:0045879 (negative regulation of smoothened signaling pathway)
GO:0045880 (positive regulation of smoothened signaling pathway)
GO:0046777 (protein autophosphorylation)
GO:0090398 (cellular senescence)

Target Cross References - Protein

canSAR Q6PHR2
Human Protein Atlas ENSG00000140474
IntAct Q6PHR2
Guide to Pharmacology 2273
Open Targets ENSG00000140474
PharmGKB PA134908392
Pharos Q6PHR2 (Tchem)
Reactome R-HSA-5632684 (Hedgehog 'on' state.)
UniProt B2RXK3 B4DFT0 B4DRQ7 D3DW68 Q6PHR2 Q9NPN5 Q9UFS4

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR007330 (MIT.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR011009 (Kinase-like_dom_sf.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR036181 (MIT_dom_sf.)
Pfam PF00069 (Pkinase)
PF04212 (MIT)

Target Cross References - Structure

PDBe 4WZX
CREDO 4WZX
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