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Target Report Card

Target Name and Classification

Target ID CHEMBL5030
Preferred Name ADAM12
Synonyms ADAM 12 | ADAM12 | Disintegrin and metalloproteinase domain-containing protein 12 | MLTN | Meltrin-alpha
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > protease > metallo protease > metallo protease mam clan > metallo protease m12b subfamily

Target Components

Component Description Relationship Accession
Disintegrin and metalloproteinase domain-containing protein 12 SINGLE PROTEIN O43184

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000148848
Ensembl ENSG00000148848
GO Cellular Component GO:0005576 (extracellular region)
GO:0005615 (extracellular space)
GO:0005654 (nucleoplasm)
GO:0005886 (plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO Molecular Function GO:0004222 (metalloendopeptidase activity)
GO:0005515 (protein binding)
GO:0008233 (peptidase activity)
GO:0008237 (metallopeptidase activity)
GO:0016787 (hydrolase activity)
GO:0017124 (SH3 domain binding)
GO:0046872 (metal ion binding)
GO Biological Process GO:0006508 (proteolysis)
GO:0007155 (cell adhesion)
GO:0007520 (myoblast fusion)
GO:0030198 (extracellular matrix organization)
GO:0045766 (positive regulation of angiogenesis)
Wikipedia ADAM12

Target Cross References - Protein

canSAR O43184
Human Protein Atlas ENSG00000148848
IntAct O43184
Guide to Pharmacology 1660
Open Targets ENSG00000148848
PharmGKB PA24507
Reactome R-HSA-177929 (Signaling by EGFR.)
R-HSA-8941237 (Invadopodia formation.)
UniProt O43184 O60470 Q5JRP0 Q5JRP1 Q6P9E3 Q6UWB0

Target Cross References - Domain

InterPro IPR000742 (EGF-like_dom.)
IPR001590 (Peptidase_M12B.)
IPR001762 (Disintegrin_dom.)
IPR002870 (Peptidase_M12B_N.)
IPR006586 (ADAM_Cys-rich.)
IPR018358 (Disintegrin_CS.)
IPR024079 (MetalloPept_cat_dom_sf.)
IPR034027 (Reprolysin_adamalysin.)
IPR036436 (Disintegrin_dom_sf.)
Pfam PF00200 (Disintegrin)
PF01421 (Reprolysin)
PF01562 (Pep_M12B_propep)
PF08516 (ADAM_CR)