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Target Report Card

Target Name and Classification

Target ID CHEMBL5014
Target Type SINGLE PROTEIN
Preferred Name Serine/threonine-protein kinase RIPK2
Synonyms CARD-containing IL-1 beta ICE-kinase | CARD-containing interleukin-1 beta-converting enzyme-associated kinase | CARDIAK | RICK | RIP-2 | RIP-like-interacting CLARP kinase | RIP2 | RIPK2 | Receptor-interacting protein 2 | Receptor-interacting serine/threonine-protein kinase 2 | Tyrosine-protein kinase RIPK2
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > tkl protein kinase group > tkl protein kinase ripk family

Target Components

Component Description Relationship Accession
Receptor-interacting serine/threonine-protein kinase 2 SINGLE PROTEIN O43353

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000104312
Ensembl ENSG00000104312
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0005856 (cytoskeleton)
GO:0031982 (vesicle)
GO:0032991 (macromolecular complex)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0004715 (non-membrane spanning protein tyrosine kinase activity)
GO:0004871 (signal transducer activity)
GO:0005102 (receptor binding)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0030274 (LIM domain binding)
GO:0042802 (identical protein binding)
GO:0042803 (protein homodimerization activity)
GO:0050700 (CARD domain binding)
GO:0089720 (caspase binding)
GO Biological Process GO:0000165 (MAPK cascade)
GO:0000187 (activation of MAPK activity)
GO:0001961 (positive regulation of cytokine-mediated signaling pathway)
GO:0002250 (adaptive immune response)
GO:0002376 (immune system process)
GO:0002827 (positive regulation of T-helper 1 type immune response)
GO:0006468 (protein phosphorylation)
GO:0006915 (apoptotic process)
GO:0006954 (inflammatory response)
GO:0007165 (signal transduction)
GO:0007249 (I-kappaB kinase/NF-kappaB signaling)
GO:0007254 (JNK cascade)
GO:0010800 (positive regulation of peptidyl-threonine phosphorylation)
GO:0010942 (positive regulation of cell death)
GO:0016310 (phosphorylation)
GO:0016579 (protein deubiquitination)
GO:0018108 (peptidyl-tyrosine phosphorylation)
GO:0031398 (positive regulation of protein ubiquitination)
GO:0031663 (lipopolysaccharide-mediated signaling pathway)
GO:0032092 (positive regulation of protein binding)
GO:0032722 (positive regulation of chemokine production)
GO:0032727 (positive regulation of interferon-alpha production)
GO:0032728 (positive regulation of interferon-beta production)
GO:0032729 (positive regulation of interferon-gamma production)
GO:0032735 (positive regulation of interleukin-12 production)
GO:0032743 (positive regulation of interleukin-2 production)
GO:0032755 (positive regulation of interleukin-6 production)
GO:0032760 (positive regulation of tumor necrosis factor production)
GO:0032874 (positive regulation of stress-activated MAPK cascade)
GO:0033091 (positive regulation of immature T cell proliferation)
GO:0033138 (positive regulation of peptidyl-serine phosphorylation)
GO:0034134 (toll-like receptor 2 signaling pathway)
GO:0034142 (toll-like receptor 4 signaling pathway)
GO:0042098 (T cell proliferation)
GO:0042981 (regulation of apoptotic process)
GO:0043065 (positive regulation of apoptotic process)
GO:0043066 (negative regulation of apoptotic process)
GO:0043123 (positive regulation of I-kappaB kinase/NF-kappaB signaling)
GO:0043330 (response to exogenous dsRNA)
GO:0045087 (innate immune response)
GO:0045627 (positive regulation of T-helper 1 cell differentiation)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0046330 (positive regulation of JNK cascade)
GO:0046641 (positive regulation of alpha-beta T cell proliferation)
GO:0050718 (positive regulation of interleukin-1 beta secretion)
GO:0050731 (positive regulation of peptidyl-tyrosine phosphorylation)
GO:0050830 (defense response to Gram-positive bacterium)
GO:0050852 (T cell receptor signaling pathway)
GO:0051092 (positive regulation of NF-kappaB transcription factor activity)
GO:0070374 (positive regulation of ERK1 and ERK2 cascade)
GO:0070423 (nucleotide-binding oligomerization domain containing signaling pathway)
GO:0070427 (nucleotide-binding oligomerization domain containing 1 signaling pathway)
GO:0070431 (nucleotide-binding oligomerization domain containing 2 signaling pathway)
GO:0070498 (interleukin-1-mediated signaling pathway)
GO:0070555 (response to interleukin-1)
GO:0070671 (response to interleukin-12)
GO:0070673 (response to interleukin-18)
GO:0071222 (cellular response to lipopolysaccharide)
GO:0071223 (cellular response to lipoteichoic acid)
GO:0071224 (cellular response to peptidoglycan)
GO:0071225 (cellular response to muramyl dipeptide)
GO:0097202 (activation of cysteine-type endopeptidase activity)
GO:1904417 (positive regulation of xenophagy)
Wikipedia RIPK2

Target Cross References - Protein

canSAR O43353
Human Protein Atlas ENSG00000104312
IntAct O43353
Guide to Pharmacology 2190
Open Targets ENSG00000104312
PharmGKB PA34395
Pharos O43353 (Tchem)
Reactome R-HSA-168638 (NOD1/2 Signaling Pathway.)
R-HSA-202424 (Downstream TCR signaling.)
R-HSA-209543 (p75NTR recruits signalling complexes.)
R-HSA-445989 (TAK1 activates NFkB by phosphorylation and activation of IKKs complex.)
R-HSA-450302 (activated TAK1 mediates p38 MAPK activation.)
R-HSA-450321 (JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1.)
R-HSA-5689896 (Ovarian tumor domain proteases.)
R-HSA-9020702 (Interleukin-1 signaling.)
UniProt B7Z748 O43353 Q6UWF0

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR001245 (Ser-Thr/Tyr_kinase_cat_dom.)
IPR001315 (CARD.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR011009 (Kinase-like_dom_sf.)
IPR011029 (DEATH-like_dom_sf.)
IPR017322 (Rcpt-int_Ser/Thr_kinase-2.)
Pfam PF00619 (CARD)
PF07714 (Pkinase_Tyr)

Target Cross References - Structure

PDBe 4C8B 5AR2 5AR3 5AR4 5AR5 5AR7 5AR8 5J79 5J7B 5NG0 5NG2 5NG3 5W5J 5W5O
CREDO 4C8B 5AR2 5AR3 5AR4 5AR5 5AR7 5AR8 5J79 5J7B 5NG0 5NG2 5NG3 5W5J 5W5O
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