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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL4981
Target Type SINGLE PROTEIN
Preferred Name Cytochrome P450 51
Synonyms CYPLI | Cyp51 | Cyp51a1 | Cytochrome P450 51A1 | Cytochrome P450-14DM | Cytochrome P45014DM | Cytochrome P450LI | LDM | Lanosterol 14-alpha demethylase | Sterol 14-alpha demethylase
Organism Rattus norvegicus
Species Group No
Protein Target Classification
  • enzyme > cytochrome p450 > cytochrome p450 family 51 > cytochrome p450 family 51a > cytochrome p450 51a1

Target Components

Component Description Relationship Accession
Lanosterol 14-alpha demethylase SINGLE PROTEIN Q64654

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005783 (endoplasmic reticulum)
GO:0005789 (endoplasmic reticulum membrane)
GO:0005886 (plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0031090 (organelle membrane)
GO:0043231 (intracellular membrane-bounded organelle)
GO Molecular Function GO:0004497 (monooxygenase activity)
GO:0005506 (iron ion binding)
GO:0008398 (sterol 14-demethylase activity)
GO:0016491 (oxidoreductase activity)
GO:0016705 (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen)
GO:0020037 (heme binding)
GO:0046872 (metal ion binding)
GO Biological Process GO:0006629 (lipid metabolic process)
GO:0006694 (steroid biosynthetic process)
GO:0006695 (cholesterol biosynthetic process)
GO:0008202 (steroid metabolic process)
GO:0008203 (cholesterol metabolic process)
GO:0016126 (sterol biosynthetic process)
GO:0033488 (cholesterol biosynthetic process via 24,25-dihydrolanosterol)
GO:0045540 (regulation of cholesterol biosynthetic process)
GO:0055114 (oxidation-reduction process)
GO:0070988 (demethylation)

Target Cross References - Protein

canSAR Q64654
Reactome R-RNO-191273 (Cholesterol biosynthesis.)
R-RNO-211976 (Endogenous sterols.)
UniProt Q64549 Q64654

Target Cross References - Domain

InterPro IPR001128 (Cyt_P450.)
IPR002403 (Cyt_P450_E_grp-IV.)
IPR017972 (Cyt_P450_CS.)
IPR036396 (Cyt_P450_sf.)
Pfam PF00067 (p450)
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