ChEMBL logo

ChEMBL

spacer
ChEMBL Statistics
  Loading Statistics...
spacer

Target Report Card

Target Name and Classification

Target ID CHEMBL4980
Target Type SINGLE PROTEIN
Preferred Name Neuronal acetylcholine receptor protein alpha-7 subunit
Synonyms Acra7 | Chrna7 | Neuronal acetylcholine receptor subunit alpha-7
Organism Rattus norvegicus
Species Group No
Protein Target Classification
  • ion channel > ligand-gated ion channel > nicotinic acetylcholine receptor > nicotinic acetylcholine receptor alpha subunit

Target Components

Component Description Relationship Accession
Neuronal acetylcholine receptor subunit alpha-7 SINGLE PROTEIN Q05941

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2094110 Neuronal acetylcholine receptor PROTEIN COMPLEX GROUP

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005737 (cytoplasm)
GO:0005886 (plasma membrane)
GO:0005892 (acetylcholine-gated channel complex)
GO:0014069 (postsynaptic density)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0030054 (cell junction)
GO:0030424 (axon)
GO:0030425 (dendrite)
GO:0030426 (growth cone)
GO:0032279 (asymmetric synapse)
GO:0042734 (presynaptic membrane)
GO:0043025 (neuronal cell body)
GO:0043197 (dendritic spine)
GO:0043198 (dendritic shaft)
GO:0044853 (plasma membrane raft)
GO:0045121 (membrane raft)
GO:0045202 (synapse)
GO:0045211 (postsynaptic membrane)
GO Molecular Function GO:0004888 (transmembrane signaling receptor activity)
GO:0005216 (ion channel activity)
GO:0005230 (extracellular ligand-gated ion channel activity)
GO:0005515 (protein binding)
GO:0008144 (drug binding)
GO:0008179 (adenylate cyclase binding)
GO:0019901 (protein kinase binding)
GO:0022848 (acetylcholine-gated cation channel activity)
GO:0042166 (acetylcholine binding)
GO:0051117 (ATPase binding)
GO:0097110 (scaffold protein binding)
GO Biological Process GO:0006811 (ion transport)
GO:0006816 (calcium ion transport)
GO:0007271 (synaptic transmission, cholinergic)
GO:0007613 (memory)
GO:0019228 (neuronal action potential)
GO:0034220 (ion transmembrane transport)
GO:0035094 (response to nicotine)
GO:0042391 (regulation of membrane potential)
GO:0042416 (dopamine biosynthetic process)
GO:0050893 (sensory processing)
GO:0060078 (regulation of postsynaptic membrane potential)
GO:0060079 (excitatory postsynaptic potential)
GO:0070374 (positive regulation of ERK1 and ERK2 cascade)
GO:0095500 (acetylcholine receptor signaling pathway)
GO:1905144 (response to acetylcholine)

Target Cross References - Protein

canSAR Q05941
IntAct Q05941
Guide to Pharmacology 468
MICAD NBK23663 (Neuronal alpha-7 nicotinic acetylcholine receptor (nAChR))
NBK51667 (Neuronal alpha-7 nicotinic acetylcholine receptor (nAChR))
NBK51669 (Neuronal alpha-7 nicotinic acetylcholine receptor (nAChR))
NBK51678 (Neuronal alpha-7 nicotinic acetylcholine receptor (nAChR))
UniProt Q05941 Q53YK2

Target Cross References - Domain

InterPro IPR002394 (Nicotinic_acetylcholine_rcpt.)
IPR006029 (Neurotrans-gated_channel_TM.)
IPR006201 (Neur_channel.)
IPR006202 (Neur_chan_lig-bd.)
IPR018000 (Neurotransmitter_ion_chnl_CS.)
IPR036719 (Neuro-gated_channel_TM_sf.)
IPR036734 (Neur_chan_lig-bd_sf.)
Pfam PF02931 (Neur_chan_LBD)
PF02932 (Neur_chan_memb)
spacer
spacer