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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL4956
Target Type SINGLE PROTEIN
Preferred Name GABA receptor alpha-2 subunit
Synonyms GABA(A) receptor subunit alpha-2 | GABRA2 | Gamma-aminobutyric acid receptor subunit alpha-2
Organism Homo sapiens
Species Group No
Protein Target Classification
  • ion channel > ligand-gated ion channel > gaba-a receptor

Target Components

Component Description Relationship Accession
Gamma-aminobutyric acid receptor subunit alpha-2 SINGLE PROTEIN P47869

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2093872 GABA-A receptor; anion channel PROTEIN COMPLEX GROUP
CHEMBL2109244 GABA-A receptor; agonist GABA site PROTEIN COMPLEX GROUP
CHEMBL2111413 GABA A receptor alpha-2/beta-2/gamma-2 PROTEIN COMPLEX
CHEMBL2109243 GABA-A receptor; benzodiazepine site PROTEIN COMPLEX GROUP
CHEMBL2094130 GABA-A receptor; alpha-2/beta-3/gamma-2 PROTEIN COMPLEX
CHEMBL3885571 Gamma-aminobutyric acid receptor subunit alpha-2/beta-2 PROTEIN COMPLEX

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL277062 BROMAZEPAM GABA receptor alpha-2 subunit positive allosteric modulator 4 PubMed PubMed PubMed PubMed PubMed
CHEMBL1783282 AZD7325 GABA receptor alpha-2 subunit positive allosteric modulator 2 Other PubMed PubMed
CHEMBL1783256 AZD6280 GABA receptor alpha-2 subunit positive allosteric modulator 1 PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000151834
Ensembl ENSG00000151834
GO Cellular Component GO:0005886 (plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0030054 (cell junction)
GO:0030285 (integral component of synaptic vesicle membrane)
GO:0030659 (cytoplasmic vesicle membrane)
GO:0031410 (cytoplasmic vesicle)
GO:0034707 (chloride channel complex)
GO:0045202 (synapse)
GO:0045211 (postsynaptic membrane)
GO:1902711 (GABA-A receptor complex)
GO Molecular Function GO:0004888 (transmembrane signaling receptor activity)
GO:0004890 (GABA-A receptor activity)
GO:0005216 (ion channel activity)
GO:0005230 (extracellular ligand-gated ion channel activity)
GO:0005254 (chloride channel activity)
GO:0008503 (benzodiazepine receptor activity)
GO:0022851 (GABA-gated chloride ion channel activity)
GO Biological Process GO:0001505 (regulation of neurotransmitter levels)
GO:0006811 (ion transport)
GO:0006821 (chloride transport)
GO:0006836 (neurotransmitter transport)
GO:0007214 (gamma-aminobutyric acid signaling pathway)
GO:0034220 (ion transmembrane transport)
GO:1902476 (chloride transmembrane transport)
Wikipedia GABRA2

Target Cross References - Protein

canSAR P47869
Human Protein Atlas ENSG00000151834
IntAct P47869
Guide to Pharmacology 405
Open Targets ENSG00000151834
PharmGKB PA28490
Pharos P47869 (Tclin)
Reactome R-HSA-112314 (Neurotransmitter receptors and postsynaptic signal transmission.)
R-HSA-977441 (GABA A receptor activation.)
UniProt A8K0U7 B7Z1H8 P47869 Q59G14

Target Cross References - Domain

InterPro IPR001390 (GABAAa_rcpt.)
IPR005432 (GABBAa2_rcpt.)
IPR006028 (GABAA/Glycine_rcpt.)
IPR006029 (Neurotrans-gated_channel_TM.)
IPR006201 (Neur_channel.)
IPR006202 (Neur_chan_lig-bd.)
IPR018000 (Neurotransmitter_ion_chnl_CS.)
IPR036719 (Neuro-gated_channel_TM_sf.)
IPR036734 (Neur_chan_lig-bd_sf.)
Pfam PF02931 (Neur_chan_LBD)
PF02932 (Neur_chan_memb)
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