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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL4937
Target Type SINGLE PROTEIN
Preferred Name Casein kinase I epsilon
Synonyms CKI-epsilon | CKIe | CSNK1E | Casein kinase I isoform epsilon
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > ck1 protein kinase group > ck1 protein kinase ck1 family

Target Components

Component Description Relationship Accession
Casein kinase I isoform epsilon SINGLE PROTEIN P49674

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3038494 Casein kinase I delta/epsilon PROTEIN COMPLEX
CHEMBL2111458 Casein kinase I PROTEIN FAMILY
CHEMBL3883308 Axin-1/Casein kinase I epsilon PROTEIN-PROTEIN INTERACTION

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000213923
Ensembl ENSG00000213923
GO Cellular Component GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0003723 (RNA binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO Biological Process GO:0000086 (G2/M transition of mitotic cell cycle)
GO:0006281 (DNA repair)
GO:0006364 (rRNA processing)
GO:0006468 (protein phosphorylation)
GO:0006897 (endocytosis)
GO:0007165 (signal transduction)
GO:0008360 (regulation of cell shape)
GO:0010389 (regulation of G2/M transition of mitotic cell cycle)
GO:0016055 (Wnt signaling pathway)
GO:0016310 (phosphorylation)
GO:0018105 (peptidyl-serine phosphorylation)
GO:0032091 (negative regulation of protein binding)
GO:0032436 (positive regulation of proteasomal ubiquitin-dependent protein catabolic process)
GO:0032922 (circadian regulation of gene expression)
GO:0042752 (regulation of circadian rhythm)
GO:0048511 (rhythmic process)
GO:0060070 (canonical Wnt signaling pathway)
GO:0097711 (ciliary basal body-plasma membrane docking)
GO:1903827 (regulation of cellular protein localization)
GO:1905426 (positive regulation of Wnt-mediated midbrain dopaminergic neuron differentiation)
GO:2000052 (positive regulation of non-canonical Wnt signaling pathway)
Wikipedia CSNK1E

Target Cross References - Protein

canSAR P49674
Human Protein Atlas ENSG00000213923
IntAct P49674
Guide to Pharmacology 1998
Open Targets ENSG00000213923
PharmGKB PA26953
Pharos P49674 (Tchem)
Reactome R-HSA-201688 (WNT mediated activation of DVL.)
R-HSA-2565942 (Regulation of PLK1 Activity at G2/M Transition.)
R-HSA-380259 (Loss of Nlp from mitotic centrosomes.)
R-HSA-380270 (Recruitment of mitotic centrosome proteins and complexes.)
R-HSA-380284 (Loss of proteins required for interphase microtubule organization from the centrosome.)
R-HSA-380320 (Recruitment of NuMA to mitotic centrosomes.)
R-HSA-400253 (Circadian Clock.)
R-HSA-5620912 (Anchoring of the basal body to the plasma membrane.)
R-HSA-6791226 (Major pathway of rRNA processing in the nucleolus and cytosol.)
R-HSA-8854518 (AURKA Activation by TPX2.)
UniProt P49674

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR011009 (Kinase-like_dom_sf.)
IPR017441 (Protein_kinase_ATP_BS.)
Pfam PF00069 (Pkinase)

Target Cross References - Structure

PDBe 4HNI 4HOK
CREDO 4HNI 4HOK
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