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Target Report Card

Target Name and Classification

Target ID CHEMBL4931
Preferred Name 3-beta-hydroxysteroid-delta(8),delta(7)-isomerase
Synonyms 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase | Cholestenol Delta-isomerase | D8-D7 sterol isomerase | Delta(8)-Delta(7) sterol isomerase | EBP | Emopamil-binding protein
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase SINGLE PROTEIN Q15125

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3885502 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase/Delta(24)-sterol reductase PROTEIN FAMILY
CHEMBL612409 Anti-estrogen binding site (AEBS) PROTEIN COMPLEX

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000147155
Ensembl ENSG00000147155
GO Cellular Component GO:0005634 (nucleus)
GO:0005635 (nuclear envelope)
GO:0005783 (endoplasmic reticulum)
GO:0005789 (endoplasmic reticulum membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0031410 (cytoplasmic vesicle)
GO:0043231 (intracellular membrane-bounded organelle)
GO Molecular Function GO:0000247 (C-8 sterol isomerase activity)
GO:0004769 (steroid delta-isomerase activity)
GO:0004888 (transmembrane signaling receptor activity)
GO:0005515 (protein binding)
GO:0015238 (drug transmembrane transporter activity)
GO:0016853 (isomerase activity)
GO:0047750 (cholestenol delta-isomerase activity)
GO Biological Process GO:0001501 (skeletal system development)
GO:0006629 (lipid metabolic process)
GO:0006694 (steroid biosynthetic process)
GO:0006695 (cholesterol biosynthetic process)
GO:0006855 (drug transmembrane transport)
GO:0007165 (signal transduction)
GO:0008202 (steroid metabolic process)
GO:0008203 (cholesterol metabolic process)
GO:0016125 (sterol metabolic process)
GO:0016126 (sterol biosynthetic process)
GO:0030097 (hemopoiesis)
GO:0033489 (cholesterol biosynthetic process via desmosterol)
GO:0033490 (cholesterol biosynthetic process via lathosterol)

Target Cross References - Protein

canSAR Q15125
CGD Chondrodysplasia punctata 2, X-linked dominant
Human Protein Atlas ENSG00000147155
IntAct Q15125
Open Targets ENSG00000147155
PharmGKB PA27587
Reactome R-HSA-6807047 (Cholesterol biosynthesis via desmosterol.)
R-HSA-6807062 (Cholesterol biosynthesis via lathosterol.)
UniProt Q15125 Q6FGL3 Q6IBI9

Target Cross References - Domain

InterPro IPR007905 (EBP.)
IPR033118 (EXPERA.)
Pfam PF05241 (EBP)