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Target Report Card

Target Name and Classification

Target ID CHEMBL4924
Preferred Name Ribosomal protein S6 kinase alpha 6
Synonyms 90 kDa ribosomal protein S6 kinase 6 | RPS6KA6 | RSK-4 | RSK4 | Ribosomal S6 kinase 4 | Ribosomal protein S6 kinase alpha-6 | S6K-alpha-6 | p90-RSK 6 | p90RSK6 | pp90RSK4
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > camk protein kinase group > camk protein kinase rskb family > camk protein kinase rskb subfamily
  • enzyme > kinase > protein kinase > agc protein kinase group > agc protein kinase rsk family > agc protein kinase rsk subfamily

Target Components

Component Description Relationship Accession
Ribosomal protein S6 kinase alpha-6 SINGLE PROTEIN Q9UK32

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3832633 Ribosomal protein S6 kinase PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000072133
Ensembl ENSG00000072133
GO Cellular Component GO:0001650 (fibrillar center)
GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005730 (nucleolus)
GO:0005737 (cytoplasm)
GO:0005739 (mitochondrion)
GO:0005829 (cytosol)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0000287 (magnesium ion binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0046872 (metal ion binding)
GO Biological Process GO:0006468 (protein phosphorylation)
GO:0006978 (DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator)
GO:0007165 (signal transduction)
GO:0007417 (central nervous system development)
GO:0016310 (phosphorylation)
GO:0035556 (intracellular signal transduction)
GO:0045992 (negative regulation of embryonic development)
GO:0070373 (negative regulation of ERK1 and ERK2 cascade)
GO:2000381 (negative regulation of mesoderm development)

Target Cross References - Protein

canSAR Q9UK32
Human Protein Atlas ENSG00000072133
IntAct Q9UK32
Guide to Pharmacology 1530
Open Targets ENSG00000072133
PharmGKB PA34850
Pharos Q9UK32 (Tchem)
Reactome R-HSA-437239 (Recycling pathway of L1.)
R-HSA-442742 (CREB phosphorylation through the activation of Ras.)
R-HSA-444257 (RSK activation.)
UniProt B2R854 B7ZL90 Q6FHX2 Q8WX28 Q9H4S6 Q9UK32

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR000961 (AGC-kinase_C.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR011009 (Kinase-like_dom_sf.)
IPR016239 (Ribosomal_S6_kinase_II.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR017892 (Pkinase_C.)
Pfam PF00069 (Pkinase)
PF00433 (Pkinase_C)