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Target Report Card

Target Name and Classification

Target ID CHEMBL4901
Preferred Name Ephrin type-B receptor 3
Synonyms EK2 | EPH-like kinase 2 | EPH-like tyrosine kinase 2 | EPHB3 | ETK2 | Embryonic kinase 2 | Ephrin type-B receptor 3 | HEK2 | TYRO6 | Tyrosine-protein kinase TYRO6 | hEK2
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > tk protein kinase group > tyrosine protein kinase eph family

Target Components

Component Description Relationship Accession
Ephrin type-B receptor 3 SINGLE PROTEIN P54753

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2363043 Ephrin receptor PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000182580
Ensembl ENSG00000182580
GO Cellular Component GO:0005576 (extracellular region)
GO:0005829 (cytosol)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0030425 (dendrite)
GO:0042995 (cell projection)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004713 (protein tyrosine kinase activity)
GO:0004714 (transmembrane receptor protein tyrosine kinase activity)
GO:0005003 (ephrin receptor activity)
GO:0005524 (ATP binding)
GO:0008046 (axon guidance receptor activity)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO Biological Process GO:0001525 (angiogenesis)
GO:0001655 (urogenital system development)
GO:0006468 (protein phosphorylation)
GO:0007169 (transmembrane receptor protein tyrosine kinase signaling pathway)
GO:0007275 (multicellular organism development)
GO:0007399 (nervous system development)
GO:0007411 (axon guidance)
GO:0007413 (axonal fasciculation)
GO:0016310 (phosphorylation)
GO:0016477 (cell migration)
GO:0018108 (peptidyl-tyrosine phosphorylation)
GO:0021952 (central nervous system projection neuron axonogenesis)
GO:0022038 (corpus callosum development)
GO:0022407 (regulation of cell-cell adhesion)
GO:0031290 (retinal ganglion cell axon guidance)
GO:0034446 (substrate adhesion-dependent cell spreading)
GO:0043087 (regulation of GTPase activity)
GO:0046777 (protein autophosphorylation)
GO:0048013 (ephrin receptor signaling pathway)
GO:0048538 (thymus development)
GO:0048546 (digestive tract morphogenesis)
GO:0050770 (regulation of axonogenesis)
GO:0051965 (positive regulation of synapse assembly)
GO:0060021 (palate development)
GO:0060996 (dendritic spine development)
GO:0060997 (dendritic spine morphogenesis)
Wikipedia EPHB3

Target Cross References - Protein

canSAR P54753
Human Protein Atlas ENSG00000182580
IntAct P54753
Guide to Pharmacology 1832
Open Targets ENSG00000182580
PharmGKB PA27826
Pharos P54753 (Tchem)
Reactome R-HSA-2682334 (EPH-Ephrin signaling.)
R-HSA-3928662 (EPHB-mediated forward signaling.)
R-HSA-3928664 (Ephrin signaling.)
R-HSA-3928665 (EPH-ephrin mediated repulsion of cells.)
UniProt P54753 Q7Z740

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR001090 (Ephrin_rcpt_lig-bd_dom.)
IPR001245 (Ser-Thr/Tyr_kinase_cat_dom.)
IPR001426 (Tyr_kinase_rcpt_V_CS.)
IPR001660 (SAM.)
IPR003961 (FN3_dom.)
IPR008266 (Tyr_kinase_AS.)
IPR008979 (Galactose-bd-like_sf.)
IPR011009 (Kinase-like_dom_sf.)
IPR011641 (Tyr-kin_ephrin_A/B_rcpt-like.)
IPR013761 (SAM/pointed_sf.)
IPR013783 (Ig-like_fold.)
IPR016257 (Tyr_kinase_ephrin_rcpt.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR020635 (Tyr_kinase_cat_dom.)
IPR027936 (Eph_TM.)
IPR034245 (EphB3_rcpt_lig-bd.)
IPR036116 (FN3_sf.)
Pfam PF00041 (fn3)
PF00536 (SAM_1)
PF01404 (Ephrin_lbd)
PF07699 (Ephrin_rec_like)
PF07714 (Pkinase_Tyr)
PF14575 (EphA2_TM)

Target Cross References - Structure

PDBe 3P1I 3ZFY 5L6O 5L6P