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Target Report Card

Target Name and Classification

Target ID CHEMBL4897
Target Type SINGLE PROTEIN
Preferred Name Serine/threonine-protein kinase PLK3
Synonyms CNK | Cytokine-inducible serine/threonine-protein kinase | FGF-inducible kinase | FNK | PLK-3 | PLK3 | PRK | Polo-like kinase 3 | Proliferation-related kinase | Serine/threonine-protein kinase PLK3
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > other protein kinase group > other protein kinase plk family

Target Components

Component Description Relationship Accession
Serine/threonine-protein kinase PLK3 SINGLE PROTEIN Q9H4B4

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000173846
Ensembl ENSG00000173846
GO Cellular Component GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005730 (nucleolus)
GO:0005737 (cytoplasm)
GO:0005794 (Golgi apparatus)
GO:0005795 (Golgi stack)
GO:0005813 (centrosome)
GO:0005815 (microtubule organizing center)
GO:0005856 (cytoskeleton)
GO:0030425 (dendrite)
GO:0043025 (neuronal cell body)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0002039 (p53 binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO Biological Process GO:0000082 (G1/S transition of mitotic cell cycle)
GO:0000086 (G2/M transition of mitotic cell cycle)
GO:0000122 (negative regulation of transcription from RNA polymerase II promoter)
GO:0000302 (response to reactive oxygen species)
GO:0006468 (protein phosphorylation)
GO:0006915 (apoptotic process)
GO:0006970 (response to osmotic stress)
GO:0006974 (cellular response to DNA damage stimulus)
GO:0006977 (DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest)
GO:0007049 (cell cycle)
GO:0007093 (mitotic cell cycle checkpoint)
GO:0007113 (endomitotic cell cycle)
GO:0009314 (response to radiation)
GO:0016310 (phosphorylation)
GO:0031122 (cytoplasmic microtubule organization)
GO:0032465 (regulation of cytokinesis)
GO:0043066 (negative regulation of apoptotic process)
GO:0043491 (protein kinase B signaling)
GO:0044819 (mitotic G1/S transition checkpoint)
GO:0051302 (regulation of cell division)
GO:0090166 (Golgi disassembly)
GO:0090316 (positive regulation of intracellular protein transport)
GO:1901796 (regulation of signal transduction by p53 class mediator)
GO:1904716 (positive regulation of chaperone-mediated autophagy)
GO:2000777 (positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia)
Wikipedia PLK3

Target Cross References - Protein

canSAR Q9H4B4
Human Protein Atlas ENSG00000173846
IntAct Q9H4B4
Guide to Pharmacology 2170
Open Targets ENSG00000173846
PharmGKB PA26664
Pharos Q9H4B4 (Tchem)
Reactome R-HSA-6804115 (TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain.)
R-HSA-6804756 (Regulation of TP53 Activity through Phosphorylation.)
UniProt Q15767 Q5JR99 Q96CV1 Q9H4B4

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR000959 (POLO_box_dom.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR011009 (Kinase-like_dom_sf.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR020658 (Ser/Thr_kinase_Plk3.)
IPR033695 (POLO_box_2.)
IPR033701 (POLO_box_1.)
IPR036947 (POLO_box_dom_sf.)
Pfam PF00069 (Pkinase)
PF00659 (POLO_box)

Target Cross References - Structure

PDBe 4B6L
CREDO 4B6L
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