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Target Report Card

Target Name and Classification

Target ID CHEMBL4895
Preferred Name Tyrosine-protein kinase receptor UFO
Synonyms AXL oncogene | AXL | Tyrosine-protein kinase receptor UFO | UFO
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > tk protein kinase group > tyrosine protein kinase axl family

Target Components

Component Description Relationship Accession
Tyrosine-protein kinase receptor UFO SINGLE PROTEIN P30530

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL3301622 GILTERITINIB Tyrosine-protein kinase receptor UFO inhibitor 3 Other PubMed PubMed
CHEMBL2023349 R428 Tyrosine-protein kinase receptor UFO inhibitor 2 Other PubMed
CHEMBL3545236 BPI-9016 Tyrosine-protein kinase receptor UFO inhibitor 1 ClinicalTrials

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000167601
Ensembl ENSG00000167601
GO Cellular Component GO:0005615 (extracellular space)
GO:0005622 (intracellular)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0009986 (cell surface)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0044228 (host cell surface)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0001618 (virus receptor activity)
GO:0001786 (phosphatidylserine binding)
GO:0004672 (protein kinase activity)
GO:0004713 (protein tyrosine kinase activity)
GO:0004714 (transmembrane receptor protein tyrosine kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0032036 (myosin heavy chain binding)
GO:0043548 (phosphatidylinositol 3-kinase binding)
GO:0046982 (protein heterodimerization activity)
GO Biological Process GO:0001764 (neuron migration)
GO:0001779 (natural killer cell differentiation)
GO:0001818 (negative regulation of cytokine production)
GO:0001961 (positive regulation of cytokine-mediated signaling pathway)
GO:0001974 (blood vessel remodeling)
GO:0002376 (immune system process)
GO:0006468 (protein phosphorylation)
GO:0006909 (phagocytosis)
GO:0006954 (inflammatory response)
GO:0007165 (signal transduction)
GO:0007167 (enzyme linked receptor protein signaling pathway)
GO:0007283 (spermatogenesis)
GO:0016032 (viral process)
GO:0016310 (phosphorylation)
GO:0018108 (peptidyl-tyrosine phosphorylation)
GO:0021885 (forebrain cell migration)
GO:0030154 (cell differentiation)
GO:0030168 (platelet activation)
GO:0031100 (organ regeneration)
GO:0031668 (cellular response to extracellular stimulus)
GO:0032689 (negative regulation of interferon-gamma production)
GO:0032720 (negative regulation of tumor necrosis factor production)
GO:0032825 (positive regulation of natural killer cell differentiation)
GO:0032940 (secretion by cell)
GO:0034101 (erythrocyte homeostasis)
GO:0034446 (substrate adhesion-dependent cell spreading)
GO:0035457 (cellular response to interferon-alpha)
GO:0042698 (ovulation cycle)
GO:0043066 (negative regulation of apoptotic process)
GO:0043277 (apoptotic cell clearance)
GO:0043491 (protein kinase B signaling)
GO:0043524 (negative regulation of neuron apoptotic process)
GO:0045087 (innate immune response)
GO:0046718 (viral entry into host cell)
GO:0048010 (vascular endothelial growth factor receptor signaling pathway)
GO:0048469 (cell maturation)
GO:0048549 (positive regulation of pinocytosis)
GO:0051250 (negative regulation of lymphocyte activation)
GO:0051897 (positive regulation of protein kinase B signaling)
GO:0060068 (vagina development)
GO:0070301 (cellular response to hydrogen peroxide)
GO:0071222 (cellular response to lipopolysaccharide)
GO:0097028 (dendritic cell differentiation)
GO:0097350 (neutrophil clearance)
GO:2000669 (negative regulation of dendritic cell apoptotic process)
Wikipedia AXL_receptor_tyrosine_kinase

Target Cross References - Protein

canSAR P30530
Human Protein Atlas ENSG00000167601
IntAct P30530
Guide to Pharmacology 1835
Open Targets ENSG00000167601
PharmGKB PA25197
Pharos P30530 (Tchem)
Reactome R-HSA-4420097 (VEGFA-VEGFR2 Pathway.)
UniProt P30530 Q8N5L2 Q9UD27

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR001245 (Ser-Thr/Tyr_kinase_cat_dom.)
IPR003599 (Ig_sub.)
IPR003961 (FN3_dom.)
IPR007110 (Ig-like_dom.)
IPR008266 (Tyr_kinase_AS.)
IPR011009 (Kinase-like_dom_sf.)
IPR013783 (Ig-like_fold.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR020635 (Tyr_kinase_cat_dom.)
IPR036116 (FN3_sf.)
IPR036179 (Ig-like_dom_sf.)
Pfam PF00041 (fn3)
PF07714 (Pkinase_Tyr)

Target Cross References - Structure

PDBe 2C5D 4RA0 5U6B 5VXZ