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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL4893
Target Type SINGLE PROTEIN
Preferred Name Hepatitis C virus NS3 protease/helicase
Synonyms Genome polyprotein | NS3
Organism Hepatitis C virus
Species Group No
Protein Target Classification
  • enzyme > protease > serine protease > serine protease pa clan > serine protease s29 family

Target Components

Component Description Relationship Accession
Genome polyprotein SINGLE PROTEIN A3EZI9

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2095231 Hepatitis C virus serine protease, NS3/NS4A PROTEIN COMPLEX

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0019012 (virion)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0003968 (RNA-directed RNA polymerase activity)
GO:0004386 (helicase activity)
GO:0005524 (ATP binding)
GO:0008026 (ATP-dependent helicase activity)
GO:0008236 (serine-type peptidase activity)
GO:0016740 (transferase activity)
GO:0016779 (nucleotidyltransferase activity)
GO:0016787 (hydrolase activity)
GO Biological Process GO:0001172 (transcription, RNA-templated)
GO:0006508 (proteolysis)
GO:0019079 (viral genome replication)
GO:0019087 (transformation of host cell by virus)

Target Cross References - Protein

canSAR A3EZI9
UniProt A3EZI9

Target Cross References - Domain

InterPro IPR001650 (Helicase_C.)
IPR004109 (Peptidase_S29.)
IPR009003 (Peptidase_S1_PA.)
IPR011492 (DEAD_Flavivir.)
IPR014001 (Helicase_ATP-bd.)
IPR027417 (P-loop_NTPase.)
Pfam PF02907 (Peptidase_S29)
PF07652 (Flavi_DEAD)
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