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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL4892
Target Type SINGLE PROTEIN
Preferred Name Alpha-1a adrenergic receptor
Synonyms ADRA1A | ADRA1C | Alpha-1A adrenergic receptor | Alpha-1A adrenoceptor | Alpha-1A adrenoreceptor | Alpha-1C adrenergic receptor
Organism Bos taurus
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > small molecule receptor (family a gpcr) > monoamine receptor > adrenergic receptor

Target Components

Component Description Relationship Accession
Alpha-1A adrenergic receptor SINGLE PROTEIN P18130

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2111420 Cerebral cortex alpha adrenergic receptor PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005634 (nucleus)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0031965 (nuclear membrane)
GO Molecular Function GO:0004871 (signal transducer activity)
GO:0004930 (G-protein coupled receptor activity)
GO:0004935 (adrenergic receptor activity)
GO:0004937 (alpha1-adrenergic receptor activity)
GO:0046982 (protein heterodimerization activity)
GO Biological Process GO:0001994 (norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure)
GO:0006937 (regulation of muscle contraction)
GO:0007165 (signal transduction)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007200 (phospholipase C-activating G-protein coupled receptor signaling pathway)
GO:0007204 (positive regulation of cytosolic calcium ion concentration)
GO:0007267 (cell-cell signaling)
GO:0019229 (regulation of vasoconstriction)
GO:0043410 (positive regulation of MAPK cascade)
GO:0045907 (positive regulation of vasoconstriction)
GO:0045987 (positive regulation of smooth muscle contraction)
GO:0055117 (regulation of cardiac muscle contraction)
GO:0071880 (adenylate cyclase-activating adrenergic receptor signaling pathway)

Target Cross References - Protein

canSAR P18130
UniProt P18130

Target Cross References - Domain

InterPro IPR000276 (GPCR_Rhodpsn.)
IPR001004 (ADRA1A_rcpt.)
IPR002233 (ADR_fam.)
IPR017452 (GPCR_Rhodpsn_7TM.)
Pfam PF00001 (7tm_1)
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