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Target Report Card

Target Name and Classification

Target ID CHEMBL4878
Preferred Name Cytochrome P450 1B1
Synonyms CYP1B1 | CYPIB1 | Cytochrome P450 1B1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > cytochrome p450 > cytochrome p450 family 1 > cytochrome p450 family 1b > cytochrome p450 1b1

Target Components

Component Description Relationship Accession
Cytochrome P450 1B1 SINGLE PROTEIN Q16678

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000138061
Ensembl ENSG00000138061
GO Cellular Component GO:0005739 (mitochondrion)
GO:0005783 (endoplasmic reticulum)
GO:0005789 (endoplasmic reticulum membrane)
GO:0016020 (membrane)
GO:0031090 (organelle membrane)
GO:0043231 (intracellular membrane-bounded organelle)
GO Molecular Function GO:0004497 (monooxygenase activity)
GO:0005506 (iron ion binding)
GO:0016491 (oxidoreductase activity)
GO:0016705 (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen)
GO:0016712 (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen)
GO:0019825 (oxygen binding)
GO:0020037 (heme binding)
GO:0046872 (metal ion binding)
GO:0070330 (aromatase activity)
GO Biological Process GO:0001525 (angiogenesis)
GO:0002930 (trabecular meshwork development)
GO:0006725 (cellular aromatic compound metabolic process)
GO:0006805 (xenobiotic metabolic process)
GO:0006809 (nitric oxide biosynthetic process)
GO:0007155 (cell adhesion)
GO:0007601 (visual perception)
GO:0008202 (steroid metabolic process)
GO:0008210 (estrogen metabolic process)
GO:0008285 (negative regulation of cell proliferation)
GO:0008631 (intrinsic apoptotic signaling pathway in response to oxidative stress)
GO:0009404 (toxin metabolic process)
GO:0009636 (response to toxic substance)
GO:0010575 (positive regulation of vascular endothelial growth factor production)
GO:0016125 (sterol metabolic process)
GO:0019369 (arachidonic acid metabolic process)
GO:0019373 (epoxygenase P450 pathway)
GO:0030199 (collagen fibril organization)
GO:0030336 (negative regulation of cell migration)
GO:0032088 (negative regulation of NF-kappaB transcription factor activity)
GO:0033629 (negative regulation of cell adhesion mediated by integrin)
GO:0042572 (retinol metabolic process)
GO:0042574 (retinal metabolic process)
GO:0043065 (positive regulation of apoptotic process)
GO:0043542 (endothelial cell migration)
GO:0045766 (positive regulation of angiogenesis)
GO:0046427 (positive regulation of JAK-STAT cascade)
GO:0046466 (membrane lipid catabolic process)
GO:0048514 (blood vessel morphogenesis)
GO:0055114 (oxidation-reduction process)
GO:0061298 (retina vasculature development in camera-type eye)
GO:0061304 (retinal blood vessel morphogenesis)
GO:0070301 (cellular response to hydrogen peroxide)
GO:0071407 (cellular response to organic cyclic compound)
GO:0071603 (endothelial cell-cell adhesion)
GO:0097267 (omega-hydroxylase P450 pathway)
GO:2000377 (regulation of reactive oxygen species metabolic process)
Wikipedia CYP1B1

Target Cross References - Protein

canSAR Q16678
CGD Glaucoma, primary open angle, adult-onset; Peters anomaly; Glaucoma 3A, primary congenital; Glaucoma, primary open angle glaucoma, juvenile-onset
Human Protein Atlas ENSG00000138061
IntAct Q16678
Guide to Pharmacology 1320
Open Targets ENSG00000138061
PharmGKB PA27094
Reactome R-HSA-211976 (Endogenous sterols.)
R-HSA-2142670 (Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET).)
R-HSA-2142816 (Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE).)
R-HSA-5579000 (Defective CYP1B1 causes Glaucoma.)
UniProt Q16678 Q5TZW8 Q93089 Q9H316

Target Cross References - Domain

InterPro IPR001128 (Cyt_P450.)
IPR002401 (Cyt_P450_E_grp-I.)
IPR017972 (Cyt_P450_CS.)
IPR032971 (CYP1B1.)
IPR036396 (Cyt_P450_sf.)
Pfam PF00067 (p450)

Target Cross References - Structure