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Target Report Card

Target Name and Classification

Target ID CHEMBL4829
Target Type SINGLE PROTEIN
Preferred Name Acetyl-CoA carboxylase 2
Synonyms ACACB | ACC-beta | ACC2 | ACCB | Acetyl-CoA carboxylase 2 | Biotin carboxylase
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Acetyl-CoA carboxylase 2 SINGLE PROTEIN O00763

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000076555
Ensembl ENSG00000076555
GO Cellular Component GO:0005634 (nucleus)
GO:0005739 (mitochondrion)
GO:0005741 (mitochondrial outer membrane)
GO:0005829 (cytosol)
GO:0012505 (endomembrane system)
GO:0016020 (membrane)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0003824 (catalytic activity)
GO:0003989 (acetyl-CoA carboxylase activity)
GO:0004075 (biotin carboxylase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016874 (ligase activity)
GO:0046872 (metal ion binding)
GO Biological Process GO:0006084 (acetyl-CoA metabolic process)
GO:0006629 (lipid metabolic process)
GO:0006631 (fatty acid metabolic process)
GO:0006633 (fatty acid biosynthetic process)
GO:0006768 (biotin metabolic process)
GO:0006853 (carnitine shuttle)
GO:0008152 (metabolic process)
GO:0010629 (negative regulation of gene expression)
GO:0010884 (positive regulation of lipid storage)
GO:0010906 (regulation of glucose metabolic process)
GO:0031325 (positive regulation of cellular metabolic process)
GO:0031667 (response to nutrient levels)
GO:0031999 (negative regulation of fatty acid beta-oxidation)
GO:0043086 (negative regulation of catalytic activity)
GO:0046322 (negative regulation of fatty acid oxidation)
GO:0050995 (negative regulation of lipid catabolic process)
GO:0051289 (protein homotetramerization)
GO:0060421 (positive regulation of heart growth)
GO:0097009 (energy homeostasis)
GO:2001295 (malonyl-CoA biosynthetic process)
Wikipedia ACACB

Target Cross References - Protein

Human Protein Atlas ENSG00000076555
IntAct O00763
Guide to Pharmacology 1264
Open Targets ENSG00000076555
PharmGKB PA24422
Reactome R-HSA-163765 (ChREBP activates metabolic gene expression.)
R-HSA-196780 (Biotin transport and metabolism.)
R-HSA-200425 (Import of palmitoyl-CoA into the mitochondrial matrix.)
R-HSA-2426168 (Activation of gene expression by SREBF (SREBP).)
UniProt A6NK36 O00763 Q16852 Q1HEC1 Q6KE87 Q6KE89 Q6TY48

Target Cross References - Domain

InterPro IPR000022 (Carboxyl_trans.)
IPR000089 (Biotin_lipoyl.)
IPR005479 (CbamoylP_synth_lsu-like_ATP-bd.)
IPR005481 (BC-like_N.)
IPR005482 (Biotin_COase_C.)
IPR011053 (Single_hybrid_motif.)
IPR011054 (Rudment_hybrid_motif.)
IPR011761 (ATP-grasp.)
IPR011762 (COA_CT_N.)
IPR011763 (COA_CT_C.)
IPR011764 (Biotin_carboxylation_dom.)
IPR013537 (AcCoA_COase_cen.)
IPR013815 (ATP_grasp_subdomain_1.)
IPR013816 (ATP_grasp_subdomain_2.)
IPR016185 (PreATP-grasp_dom.)
IPR029045 (ClpP/crotonase-like_dom.)
Pfam PF00289 (Biotin_carb_N)
PF00364 (Biotin_lipoyl)
PF01039 (Carboxyl_trans)
PF02785 (Biotin_carb_C)
PF02786 (CPSase_L_D2)
PF08326 (ACC_central)

Target Cross References - Structure

PDBe 2HJW 3FF6 3GID 3GLK 3JRW 3JRX 3TDC 4HQ6 5KKN
CREDO 2HJW 3FF6 3GID 3GLK 3JRW 3JRX 3TDC 4HQ6 5KKN
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