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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL4808
Target Type SINGLE PROTEIN
Preferred Name Acetylcholine receptor protein alpha chain
Synonyms ACHRA | Acetylcholine receptor subunit alpha | CHNRA | CHRNA1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • ion channel > ligand-gated ion channel > nicotinic acetylcholine receptor > nicotinic acetylcholine receptor alpha subunit

Target Components

Component Description Relationship Accession
Acetylcholine receptor subunit alpha SINGLE PROTEIN P02708

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL1907588 Acetylcholine receptor; alpha1/beta1/delta/gamma PROTEIN COMPLEX
CHEMBL2362997 Muscle-type nicotinic acetylcholine receptor PROTEIN COMPLEX GROUP
CHEMBL3038459 Nicotinic acetylcholine receptor alpha2/beta4 PROTEIN COMPLEX
CHEMBL3038458 Nicotinic acetylcholine receptor alpha2/beta2 PROTEIN COMPLEX

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000138435
Ensembl ENSG00000138435
GO Cellular Component GO:0005886 (plasma membrane)
GO:0005892 (acetylcholine-gated channel complex)
GO:0009986 (cell surface)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0030054 (cell junction)
GO:0031594 (neuromuscular junction)
GO:0045202 (synapse)
GO:0045211 (postsynaptic membrane)
GO Molecular Function GO:0004889 (acetylcholine-activated cation-selective channel activity)
GO:0005216 (ion channel activity)
GO:0005230 (extracellular ligand-gated ion channel activity)
GO:0015276 (ligand-gated ion channel activity)
GO:0015464 (acetylcholine receptor activity)
GO:0042166 (acetylcholine binding)
GO Biological Process GO:0003009 (skeletal muscle contraction)
GO:0006810 (transport)
GO:0006811 (ion transport)
GO:0006812 (cation transport)
GO:0007165 (signal transduction)
GO:0007271 (synaptic transmission, cholinergic)
GO:0007274 (neuromuscular synaptic transmission)
GO:0007528 (neuromuscular junction development)
GO:0019228 (neuronal action potential)
GO:0035094 (response to nicotine)
GO:0042391 (regulation of membrane potential)
GO:0046716 (muscle cell cellular homeostasis)
GO:0048630 (skeletal muscle tissue growth)
GO:0050881 (musculoskeletal movement)
GO:0050905 (neuromuscular process)
GO:0070050 (neuron cellular homeostasis)
GO:0098655 (cation transmembrane transport)
GO:0099565 (chemical synaptic transmission, postsynaptic)
Wikipedia Cholinergic_receptor,_nicotinic,_alpha_1

Target Cross References - Protein

canSAR P02708
CGD Myasthenic syndrome, congenital, fast channel; Myasthenic syndrome, slow-channel congenital
Human Protein Atlas ENSG00000138435
IntAct P02708
Guide to Pharmacology 462
Open Targets ENSG00000138435
PharmGKB PA26487
Pharos P02708 (Tclin)
Reactome R-HSA-629594 (Highly calcium permeable postsynaptic nicotinic acetylcholine receptors.)
R-HSA-629597 (Highly calcium permeable nicotinic acetylcholine receptors.)
UniProt B4DRV6 D3DPE8 P02708

Target Cross References - Domain

InterPro IPR002394 (Nicotinic_acetylcholine_rcpt.)
IPR006029 (Neurotrans-gated_channel_TM.)
IPR006201 (Neur_channel.)
IPR006202 (Neur_chan_lig-bd.)
IPR018000 (Neurotransmitter_ion_chnl_CS.)
IPR027361 (Acetylcholine_rcpt_TM.)
Pfam PF02931 (Neur_chan_LBD)
PF02932 (Neur_chan_memb)

Target Cross References - Structure

PDBe 4ZJS
CREDO 4ZJS
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