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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL4787
Target Type SINGLE PROTEIN
Preferred Name Glutamate [NMDA] receptor subunit 3A
Synonyms GRIN3A | GluN3A | Glutamate receptor ionotropic, NMDA 3A | KIAA1973 | N-methyl-D-aspartate receptor subtype 3A | NMDAR-L | NMDAR3A | NR3A
Organism Homo sapiens
Species Group No
Protein Target Classification
  • ion channel > ligand-gated ion channel > ionotropic glutamate receptor > nmda receptor

Target Components

Component Description Relationship Accession
Glutamate receptor ionotropic, NMDA 3A SINGLE PROTEIN Q8TCU5

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2094124 Glutamate [NMDA] receptor PROTEIN COMPLEX GROUP

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000198785
Ensembl ENSG00000198785
GO Cellular Component GO:0005886 (plasma membrane)
GO:0014069 (postsynaptic density)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0017146 (NMDA selective glutamate receptor complex)
GO:0030054 (cell junction)
GO:0043005 (neuron projection)
GO:0043025 (neuronal cell body)
GO:0045202 (synapse)
GO:0045211 (postsynaptic membrane)
GO Molecular Function GO:0004970 (ionotropic glutamate receptor activity)
GO:0004972 (NMDA glutamate receptor activity)
GO:0005216 (ion channel activity)
GO:0005234 (extracellular-glutamate-gated ion channel activity)
GO:0005262 (calcium channel activity)
GO:0005515 (protein binding)
GO:0016594 (glycine binding)
GO:0038023 (signaling receptor activity)
GO:0042802 (identical protein binding)
GO:0051721 (protein phosphatase 2A binding)
GO Biological Process GO:0006811 (ion transport)
GO:0006816 (calcium ion transport)
GO:0007165 (signal transduction)
GO:0016358 (dendrite development)
GO:0034220 (ion transmembrane transport)
GO:0035235 (ionotropic glutamate receptor signaling pathway)
GO:0045471 (response to ethanol)
GO:0060079 (excitatory postsynaptic potential)
GO:0060134 (prepulse inhibition)
GO:0070588 (calcium ion transmembrane transport)
Wikipedia GRIN3A

Target Cross References - Protein

canSAR Q8TCU5
Human Protein Atlas ENSG00000198785
Open Targets ENSG00000198785
PharmGKB PA28983
Pharos Q8TCU5 (Tclin)
UniProt B3DLF9 Q5VTR3 Q8TCU5 Q8TF29 Q8WXI6

Target Cross References - Domain

InterPro IPR001320 (Iontro_rcpt.)
IPR001508 (Iono_rcpt_met.)
IPR019594 (Glu/Gly-bd.)
IPR028082 (Peripla_BP_I.)
Pfam PF00060 (Lig_chan)
PF10613 (Lig_chan-Glu_bd)
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