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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL4780
Target Type SINGLE PROTEIN
Preferred Name Acetylcholinesterase
Synonyms AChE | Acetylcholinesterase | ache
Organism Torpedo californica
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Acetylcholinesterase SINGLE PROTEIN P04058

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005886 (plasma membrane)
GO:0016020 (membrane)
GO:0030054 (cell junction)
GO:0031225 (anchored component of membrane)
GO:0043083 (synaptic cleft)
GO:0045202 (synapse)
GO Molecular Function GO:0003990 (acetylcholinesterase activity)
GO:0004104 (cholinesterase activity)
GO:0016787 (hydrolase activity)
GO:0052689 (carboxylic ester hydrolase activity)
GO Biological Process GO:0001507 (acetylcholine catabolic process in synaptic cleft)
GO:0042135 (neurotransmitter catabolic process)

Target Cross References - Protein

canSAR P04058
UniProt P04058

Target Cross References - Domain

InterPro IPR000908 (Acylcholinesterase_fish/snake.)
IPR000997 (Cholinesterase.)
IPR002018 (CarbesteraseB.)
IPR019819 (Carboxylesterase_B_CS.)
IPR019826 (Carboxylesterase_B_AS.)
IPR029058 (AB_hydrolase.)
Pfam PF00135 (COesterase)

Target Cross References - Structure

PDBe 1ACJ 1ACL 1AMN 1AX9 1CFJ 1DX6 1E3Q 1E66 1EA5 1EEA 1EVE 1FSS 1GPK 1GPN 1GQR 1GQS 1H22 1H23 1HBJ 1JJB 1OCE 1ODC 1QID 1QIE More...
CREDO 1ACJ 1ACL 1AMN 1AX9 1CFJ 1DX6 1E3Q 1E66 1EA5 1EEA 1EVE 1FSS 1GPK 1GPN 1GQR 1GQS 1H22 1H23 1HBJ 1JJB 1OCE 1ODC 1QID 1QIE More...
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