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Target Report Card

Target Name and Classification

Target ID CHEMBL4763
Target Type SINGLE PROTEIN
Preferred Name Serine/threonine protein phosphatase 2A, 56 kDa regulatory subunit, alpha isoform
Synonyms PP2A B subunit isoform B'-alpha | PP2A B subunit isoform B56-alpha | PP2A B subunit isoform PR61-alpha | PP2A B subunit isoform R5-alpha | PPP2R5A | PR61alpha | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > phosphatase > protein phosphatase > protein phosphatase regulatory subunit

Target Components

Component Description Relationship Accession
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform SINGLE PROTEIN Q15172

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000066027
Ensembl ENSG00000066027
GO Cellular Component GO:0000159 (protein phosphatase type 2A complex)
GO:0000775 (chromosome, centromeric region)
GO:0005634 (nucleus)
GO:0005694 (chromosome)
GO:0005737 (cytoplasm)
GO:0016020 (membrane)
GO:0030018 (Z disc)
GO:0031430 (M band)
GO Molecular Function GO:0005515 (protein binding)
GO:0008601 (protein phosphatase type 2A regulator activity)
GO:0019900 (kinase binding)
GO Biological Process GO:0007165 (signal transduction)
GO:0034047 (regulation of protein phosphatase type 2A activity)
GO:0035307 (positive regulation of protein dephosphorylation)
GO:0090005 (negative regulation of establishment of protein localization to plasma membrane)
GO:0090219 (negative regulation of lipid kinase activity)
Wikipedia PPP2R5A

Target Cross References - Protein

canSAR Q15172
Human Protein Atlas ENSG00000066027
IntAct Q15172
Open Targets ENSG00000066027
PharmGKB PA33672
Reactome R-HSA-195253 (Degradation of beta-catenin by the destruction complex.)
R-HSA-196299 (Beta-catenin phosphorylation cascade.)
R-HSA-2467813 (Separation of Sister Chromatids.)
R-HSA-2500257 (Resolution of Sister Chromatid Cohesion.)
R-HSA-389513 (CTLA4 inhibitory signaling.)
R-HSA-432142 (Platelet sensitization by LDL.)
R-HSA-4641262 (Disassembly of the destruction complex and recruitment of AXIN to the membrane.)
R-HSA-5339716 (Misspliced GSK3beta mutants stabilize beta-catenin.)
R-HSA-5358747 (S33 mutants of beta-catenin aren't phosphorylated.)
R-HSA-5358749 (S37 mutants of beta-catenin aren't phosphorylated.)
R-HSA-5358751 (S45 mutants of beta-catenin aren't phosphorylated.)
R-HSA-5358752 (T41 mutants of beta-catenin aren't phosphorylated.)
R-HSA-5467337 (APC truncation mutants have impaired AXIN binding.)
R-HSA-5467340 (AXIN missense mutants destabilize the destruction complex.)
R-HSA-5467348 (Truncations of AMER1 destabilize the destruction complex.)
R-HSA-5663220 (RHO GTPases Activate Formins.)
R-HSA-5673000 (RAF activation.)
R-HSA-5675221 (Negative regulation of MAPK pathway.)
R-HSA-6811558 (PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.)
R-HSA-68877 (Mitotic Prometaphase.)
UniProt B2R6D2 B7Z7L2 D3DT99 Q15172 Q2NL72 Q5VVB2 Q8TBI9

Target Cross References - Domain

InterPro IPR002554 (PP2A_B56.)
IPR016024 (ARM-type_fold.)
Pfam PF01603 (B56)
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