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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL4744
Target Type SINGLE PROTEIN
Preferred Name Alpha-2a adrenergic receptor
Synonyms ADRA2A | Alpha-2A adrenergic receptor | Alpha-2A adrenoceptor | Alpha-2A adrenoreceptor | Alpha-2AAR | Alpha-2D adrenergic receptor
Organism Bos taurus
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > small molecule receptor (family a gpcr) > monoamine receptor > adrenergic receptor

Target Components

Component Description Relationship Accession
Alpha-2A adrenergic receptor SINGLE PROTEIN Q28838

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2111420 Cerebral cortex alpha adrenergic receptor PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO Molecular Function GO:0004871 (signal transducer activity)
GO:0004930 (G-protein coupled receptor activity)
GO:0004935 (adrenergic receptor activity)
GO:0004938 (alpha2-adrenergic receptor activity)
GO Biological Process GO:0006940 (regulation of smooth muscle contraction)
GO:0007165 (signal transduction)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007267 (cell-cell signaling)
GO:0019229 (regulation of vasoconstriction)
GO:0030168 (platelet activation)
GO:0071880 (adenylate cyclase-activating adrenergic receptor signaling pathway)

Target Cross References - Protein

canSAR Q28838
UniProt Q28838

Target Cross References - Domain

InterPro IPR000276 (GPCR_Rhodpsn.)
IPR001946 (ADRA2A_rcpt.)
IPR002233 (ADR_fam.)
IPR017452 (GPCR_Rhodpsn_7TM.)
Pfam PF00001 (7tm_1)
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