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Target Report Card

Target Name and Classification

Target ID CHEMBL4701
Preferred Name Histamine H1 receptor
Synonyms H1R | HH1R | Histamine H1 receptor | Hrh1
Organism Rattus norvegicus
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > small molecule receptor (family a gpcr) > monoamine receptor > histamine receptor

Target Components

Component Description Relationship Accession
Histamine H1 receptor SINGLE PROTEIN P31390

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO Molecular Function GO:0004871 (signal transducer activity)
GO:0004930 (G-protein coupled receptor activity)
GO:0004969 (histamine receptor activity)
GO:0051381 (histamine binding)
GO Biological Process GO:0006954 (inflammatory response)
GO:0007165 (signal transduction)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007199 (G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger)
GO:0007200 (phospholipase C-activating G-protein coupled receptor signaling pathway)
GO:0007268 (chemical synaptic transmission)
GO:0009629 (response to gravity)
GO:0010894 (negative regulation of steroid biosynthetic process)
GO:0043114 (regulation of vascular permeability)
GO:0045429 (positive regulation of nitric oxide biosynthetic process)
GO:0045907 (positive regulation of vasoconstriction)
GO:0048245 (eosinophil chemotaxis)
GO:0050804 (modulation of synaptic transmission)
GO:0071420 (cellular response to histamine)

Target Cross References - Protein

canSAR P31390
UniProt P31390

Target Cross References - Domain

InterPro IPR000276 (GPCR_Rhodpsn.)
IPR000921 (Histamine_H1_rcpt.)
IPR017452 (GPCR_Rhodpsn_7TM.)
Pfam PF00001 (7tm_1)