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Target Report Card

Target Name and Classification

Target ID CHEMBL4693
Target Type SINGLE PROTEIN
Preferred Name Sarcoplasmic/endoplasmic reticulum calcium ATP-ase
Synonyms ATP2A1 | Calcium pump 1 | Calcium-transporting ATPase sarcoplasmic reticulum type, fast twitch skeletal muscle isoform | Endoplasmic reticulum class 1/2 Ca(2+) ATPase | SERCA1 | SR Ca(2+)-ATPase 1 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1
Organism Oryctolagus cuniculus
Species Group No
Protein Target Classification
  • transporter > primary active transporter > p-type atpase > calcium atpase
  • enzyme > hydrolase

Target Components

Component Description Relationship Accession
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 SINGLE PROTEIN P04191

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005783 (endoplasmic reticulum)
GO:0005789 (endoplasmic reticulum membrane)
GO:0005793 (endoplasmic reticulum-Golgi intermediate compartment)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0016529 (sarcoplasmic reticulum)
GO:0031673 (H zone)
GO:0031674 (I band)
GO:0033017 (sarcoplasmic reticulum membrane)
GO:0048471 (perinuclear region of cytoplasm)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0005388 (calcium-transporting ATPase activity)
GO:0005509 (calcium ion binding)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016787 (hydrolase activity)
GO:0046872 (metal ion binding)
GO Biological Process GO:0006810 (transport)
GO:0006811 (ion transport)
GO:0006816 (calcium ion transport)
GO:0006942 (regulation of striated muscle contraction)
GO:0031448 (positive regulation of fast-twitch skeletal muscle fiber contraction)
GO:0045988 (negative regulation of striated muscle contraction)
GO:0070588 (calcium ion transmembrane transport)

Target Cross References - Protein

canSAR P04191
IntAct P04191
UniProt P04191 P11719

Target Cross References - Domain

InterPro IPR001757 (P_typ_ATPase.)
IPR004014 (ATPase_P-typ_cation-transptr_N.)
IPR005782 (P-type_ATPase_IIA.)
IPR006068 (ATPase_P-typ_cation-transptr_C.)
IPR008250 (ATPase_P-typ_transduc_dom_A.)
IPR018303 (ATPase_P-typ_P_site.)
IPR023214 (HAD-like_dom.)
IPR023298 (ATPase_P-typ_TM_dom.)
IPR023299 (ATPase_P-typ_cyto_domN.)
IPR030332 (SERCA1.)
Pfam PF00122 (E1-E2_ATPase)
PF00689 (Cation_ATPase_C)
PF00690 (Cation_ATPase_N)
PF08282 (Hydrolase_3)

Target Cross References - Structure

PDBe 1IWO 1SU4 1T5S 1T5T 1VFP 1WPG 1XP5 2AGV 2BY4 2C88 2C8K 2C8L 2C9M 2DQS 2EAR 2EAT 2EAU 2O9J 2OA0 2YFY 2ZBD 2ZBE 2ZBF 2ZBG More...
CREDO 1IWO 1SU4 1T5S 1T5T 1VFP 1WPG 1XP5 2AGV 2BY4 2C88 2C8K 2C8L 2C9M 2DQS 2EAR 2EAT 2EAU 2O9J 2OA0 2YFY 2ZBD 2ZBE 2ZBF 2ZBG More...
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