ChEMBL logo


ChEMBL Statistics
  Loading Statistics...

Target Report Card

Target Name and Classification

Target ID CHEMBL4681
Preferred Name Aldo-keto-reductase family 1 member C3
Synonyms 17-beta-HSD 5 | 17-beta-hydroxysteroid dehydrogenase type 5 | 3-alpha-HSD type 2 | 3-alpha-HSD type II, brain | 3-alpha-hydroxysteroid dehydrogenase type 2 | AKR1C3 | Aldo-keto reductase family 1 member C3 | Chlordecone reductase homolog HAKRb | DD-3 | DD3 | DDH1 | Dihydrodiol dehydrogenase 3 | Dihydrodiol dehydrogenase type I | HA1753 | HSD17B5 | Indanol dehydrogenase | KIAA0119 | PGFS | PGFS | Prostaglandin F synthase | Testosterone 17-beta-dehydrogenase 5 | Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Aldo-keto reductase family 1 member C3 SINGLE PROTEIN P42330

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000196139
Ensembl ENSG00000196139
GO Cellular Component GO:0005622 (intracellular)
GO:0005634 (nucleus)
GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0001758 (retinal dehydrogenase activity)
GO:0004032 (alditol:NADP+ 1-oxidoreductase activity)
GO:0004033 (aldo-keto reductase (NADP) activity)
GO:0004745 (retinol dehydrogenase activity)
GO:0016491 (oxidoreductase activity)
GO:0016655 (oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor)
GO:0018636 (phenanthrene 9,10-monooxygenase activity)
GO:0035410 (dihydrotestosterone 17-beta-dehydrogenase activity)
GO:0036130 (prostaglandin H2 endoperoxidase reductase activity)
GO:0036131 (prostaglandin D2 11-ketoreductase activity)
GO:0045550 (geranylgeranyl reductase activity)
GO:0045703 (ketoreductase activity)
GO:0047017 (prostaglandin-F synthase activity)
GO:0047020 (15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity)
GO:0047023 (androsterone dehydrogenase activity)
GO:0047035 (testosterone dehydrogenase (NAD+) activity)
GO:0047045 (testosterone 17-beta-dehydrogenase (NADP+) activity)
GO:0047086 (ketosteroid monooxygenase activity)
GO:0047115 (trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity)
GO:0047718 (indanol dehydrogenase activity)
GO:0047787 (delta4-3-oxosteroid 5beta-reductase activity)
GO:0052650 (NADP-retinol dehydrogenase activity)
GO Biological Process GO:0000060 (protein import into nucleus, translocation)
GO:0001523 (retinoid metabolic process)
GO:0006693 (prostaglandin metabolic process)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007584 (response to nutrient)
GO:0008202 (steroid metabolic process)
GO:0008284 (positive regulation of cell proliferation)
GO:0008584 (male gonad development)
GO:0009267 (cellular response to starvation)
GO:0010942 (positive regulation of cell death)
GO:0016488 (farnesol catabolic process)
GO:0019371 (cyclooxygenase pathway)
GO:0030216 (keratinocyte differentiation)
GO:0034614 (cellular response to reactive oxygen species)
GO:0042448 (progesterone metabolic process)
GO:0042572 (retinol metabolic process)
GO:0042574 (retinal metabolic process)
GO:0043170 (macromolecule metabolic process)
GO:0044597 (daunorubicin metabolic process)
GO:0044598 (doxorubicin metabolic process)
GO:0048385 (regulation of retinoic acid receptor signaling pathway)
GO:0051897 (positive regulation of protein kinase B signaling)
GO:0055114 (oxidation-reduction process)
GO:0061370 (testosterone biosynthetic process)
GO:0070293 (renal absorption)
GO:0071276 (cellular response to cadmium ion)
GO:0071277 (cellular response to calcium ion)
GO:0071379 (cellular response to prostaglandin stimulus)
GO:0071384 (cellular response to corticosteroid stimulus)
GO:0071395 (cellular response to jasmonic acid stimulus)
GO:0071799 (cellular response to prostaglandin D stimulus)
GO:1900053 (negative regulation of retinoic acid biosynthetic process)
GO:2000224 (regulation of testosterone biosynthetic process)
GO:2000353 (positive regulation of endothelial cell apoptotic process)
GO:2000379 (positive regulation of reactive oxygen species metabolic process)
Wikipedia AKR1C3

Target Cross References - Protein

Human Protein Atlas ENSG00000196139
IntAct P42330
Guide to Pharmacology 1382
Open Targets ENSG00000196139
PharmGKB PA24679
Reactome R-HSA-193368 (Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol.)
R-HSA-193775 (Synthesis of bile acids and bile salts via 24-hydroxycholesterol.)
R-HSA-193807 (Synthesis of bile acids and bile salts via 27-hydroxycholesterol.)
R-HSA-2162123 (Synthesis of Prostaglandins (PG) and Thromboxanes (TX).)
R-HSA-5365859 (RA biosynthesis pathway.)
R-HSA-975634 (Retinoid metabolism and transport.)
UniProt A8K2V0 B4DL37 P42330 Q5T2L1 Q96DJ1 Q96KI8 Q99530 Q9UCX1 Q9UII3 Q9UKL9

Target Cross References - Domain

InterPro IPR018170 (Aldo/ket_reductase_CS.)
IPR020471 (Aldo/keto_reductase.)
IPR023210 (NADP_OxRdtase_dom.)
IPR036812 (NADP_OxRdtase_dom_sf.)
Pfam PF00248 (Aldo_ket_red)

Target Cross References - Structure

PDBe 1RY0 1RY8 1S1P 1S1R 1S2A 1S2C 1XF0 1ZQ5 2F38 2FGB 3R43 3R58 3R6I 3R7M 3R8G 3R8H 3R94 3UFY 3UG8 3UGR 3UWE 4DBS 4DBU 4DBW More...
CREDO 1RY0 1RY8 1S1P 1S1R 1S2A 1S2C 1XF0 1ZQ5 2F38 2FGB 3R43 3R58 3R6I 3R7M 3R8G 3R8H 3R94 3UFY 3UG8 3UGR 3UWE 4DBS 4DBU 4DBW More...