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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL4679
Target Type SINGLE PROTEIN
Preferred Name Branched-chain-amino-acid transferase
Synonyms BCAT(c) | BCAT1 | BCT1 | Branched-chain-amino-acid aminotransferase, cytosolic | ECA39 | Protein ECA39
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Branched-chain-amino-acid aminotransferase, cytosolic SINGLE PROTEIN P54687

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000060982
Ensembl ENSG00000060982
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005739 (mitochondrion)
GO:0005829 (cytosol)
GO Molecular Function GO:0003824 (catalytic activity)
GO:0004084 (branched-chain-amino-acid transaminase activity)
GO:0008483 (transaminase activity)
GO:0016740 (transferase activity)
GO:0030170 (pyridoxal phosphate binding)
GO:0042802 (identical protein binding)
GO:0052654 (L-leucine transaminase activity)
GO:0052655 (L-valine transaminase activity)
GO:0052656 (L-isoleucine transaminase activity)
GO Biological Process GO:0000082 (G1/S transition of mitotic cell cycle)
GO:0006532 (aspartate biosynthetic process)
GO:0008152 (metabolic process)
GO:0008283 (cell proliferation)
GO:0008652 (cellular amino acid biosynthetic process)
GO:0009081 (branched-chain amino acid metabolic process)
GO:0009082 (branched-chain amino acid biosynthetic process)
GO:0009083 (branched-chain amino acid catabolic process)
GO:0009098 (leucine biosynthetic process)
GO:0009099 (valine biosynthetic process)

Target Cross References - Protein

canSAR P54687
Human Protein Atlas ENSG00000060982
IntAct P54687
Open Targets ENSG00000060982
PharmGKB PA25288
Reactome R-HSA-70895 (Branched-chain amino acid catabolism.)
UniProt B3KY27 B7Z2M5 B7Z5L0 F5H5E4 P54687 Q68DQ7 Q96MY9

Target Cross References - Domain

InterPro IPR001544 (Aminotrans_IV.)
IPR005786 (B_amino_transII.)
IPR018300 (Aminotrans_IV_CS.)
Pfam PF01063 (Aminotran_4)

Target Cross References - Structure

PDBe 2ABJ 2COG 2COI 2COJ
CREDO 2ABJ 2COG 2COI 2COJ
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