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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL4677
Target Type SINGLE PROTEIN
Preferred Name Apoptosis regulator Bcl-W
Synonyms Apoptosis regulator Bcl-W | BCL2L2 | BCLW | Bcl-2-like protein 2 | Bcl2-L-2 | KIAA0271
Organism Homo sapiens
Species Group No
Protein Target Classification
  • other cytosolic protein

Target Components

Component Description Relationship Accession
Bcl-2-like protein 2 SINGLE PROTEIN Q92843

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL2107358 OBATOCLAX MESYLATE Apoptosis regulator Bcl-W inhibitor 3 PubMed PubMed PubMed
CHEMBL443684 NAVITOCLAX Apoptosis regulator Bcl-W inhibitor 2 PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000129473 ENSG00000258643
Ensembl ENSG00000129473 ENSG00000258643
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005739 (mitochondrion)
GO:0005741 (mitochondrial outer membrane)
GO:0005829 (cytosol)
GO:0016020 (membrane)
GO:0031966 (mitochondrial membrane)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0005515 (protein binding)
GO:0042803 (protein homodimerization activity)
GO:0046982 (protein heterodimerization activity)
GO:0051400 (BH domain binding)
GO Biological Process GO:0006915 (apoptotic process)
GO:0007283 (spermatogenesis)
GO:0008630 (intrinsic apoptotic signaling pathway in response to DNA damage)
GO:0042981 (regulation of apoptotic process)
GO:0043066 (negative regulation of apoptotic process)
GO:0060011 (Sertoli cell proliferation)
GO:0097192 (extrinsic apoptotic signaling pathway in absence of ligand)
GO:2001243 (negative regulation of intrinsic apoptotic signaling pathway)
Wikipedia BCL2L2

Target Cross References - Protein

Human Protein Atlas ENSG00000129473 ENSG00000258643
IntAct Q92843
Guide to Pharmacology 2846
Open Targets ENSG00000129473 ENSG00000258643
PharmGKB PA25307
UniProt A8K0F4 Q2M3U0 Q5U0H4 Q92843

Target Cross References - Domain

InterPro IPR002475 (Bcl2-like.)
IPR003093 (Bcl2_BH4.)
IPR013280 (Apop_reg_BclW.)
IPR020717 (Bcl2_BH1_motif_CS.)
IPR020726 (Bcl2_BH2_motif_CS.)
IPR020731 (Bcl2_BH4_motif_CS.)
IPR026298 (Blc2_fam.)
Pfam PF00452 (Bcl-2)
PF02180 (BH4)

Target Cross References - Structure

PDBe 2Y6W 4CIM
CREDO 2Y6W 4CIM
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