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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL4674
Target Type SINGLE PROTEIN
Preferred Name MAP kinase p38 gamma
Synonyms ERK-6 | ERK6 | Extracellular signal-regulated kinase 6 | MAP kinase 12 | MAP kinase p38 gamma | MAPK 12 | MAPK12 | Mitogen-activated protein kinase 12 | Mitogen-activated protein kinase p38 gamma | SAPK3 | Stress-activated protein kinase 3
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > cmgc protein kinase group > cmgc protein kinase mapk family > cmgc protein kinase p38 subfamily

Target Components

Component Description Relationship Accession
Mitogen-activated protein kinase 12 SINGLE PROTEIN P53778

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2094115 MAP kinase p38 PROTEIN FAMILY
CHEMBL3038503 p38 delta/gamma PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000188130
Ensembl ENSG00000188130
GO Cellular Component GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO:0005739 (mitochondrion)
GO:0005829 (cytosol)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0000287 (magnesium ion binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0004707 (MAP kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0046872 (metal ion binding)
GO Biological Process GO:0000165 (MAPK cascade)
GO:0006351 (transcription, DNA-templated)
GO:0006355 (regulation of transcription, DNA-templated)
GO:0006468 (protein phosphorylation)
GO:0006975 (DNA damage induced protein phosphorylation)
GO:0007049 (cell cycle)
GO:0007050 (cell cycle arrest)
GO:0007165 (signal transduction)
GO:0007517 (muscle organ development)
GO:0010468 (regulation of gene expression)
GO:0010952 (positive regulation of peptidase activity)
GO:0016310 (phosphorylation)
GO:0018105 (peptidyl-serine phosphorylation)
GO:0045445 (myoblast differentiation)
GO:0045786 (negative regulation of cell cycle)
GO:0048010 (vascular endothelial growth factor receptor signaling pathway)
GO:0051149 (positive regulation of muscle cell differentiation)

Target Cross References - Protein

canSAR P53778
Human Protein Atlas ENSG00000188130
IntAct P53778
Guide to Pharmacology 1501
Open Targets ENSG00000188130
PharmGKB PA30619
Pharos P53778 (Tchem)
Reactome R-HSA-168638 (NOD1/2 Signaling Pathway.)
R-HSA-171007 (p38MAPK events.)
R-HSA-2151209 (Activation of PPARGC1A (PGC-1alpha) by phosphorylation.)
R-HSA-375170 (CDO in myogenesis.)
R-HSA-376172 (DSCAM interactions.)
R-HSA-4420097 (VEGFA-VEGFR2 Pathway.)
UniProt P53778 Q14260 Q6IC53 Q99588 Q99672

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR003527 (MAP_kinase_CS.)
IPR008352 (MAPK_p38.)
IPR011009 (Kinase-like_dom_sf.)
IPR017441 (Protein_kinase_ATP_BS.)
Pfam PF00069 (Pkinase)

Target Cross References - Structure

PDBe 1CM8 4QUM
CREDO 1CM8 4QUM
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